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PKA catalytic subunit [cytosol]
Stable Identifier
R-HSA-111920
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PRKACA,PRKACB,PRKACG
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
ROBO receptors bind AKAP5 (Homo sapiens)
AKAP5 recruits PKA to ROBO2 (Homo sapiens)
PRKAR2A-PKA type II [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
ROBO2:AKAP5:PRKAR2A-PKA type II [plasma membrane] (Homo sapiens)
PRKAR2A-PKA type II [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)
Dual-specific AKAPs:PKA tetramer [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Rap1 signalling (Homo sapiens)
PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)
PKA catalytic subunits, PKG type I [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Glucagon signaling in metabolic regulation (Homo sapiens)
PKA activation in glucagon signalling (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
ER calcium channels open in response to activated PKA (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA:AKAP79:IQGAP1 Complex [plasma membrane] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride catabolism (Homo sapiens)
hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA phosphorylates PDE4B (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA activation (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP binds PKA tetramer (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
HDL assembly (Homo sapiens)
PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Homo sapiens)
PKA catalytic subunit [cytosol] (Homo sapiens)
Participants
members
PRKACA [cytosol]
(Homo sapiens)
PRKACB [cytosol]
(Homo sapiens)
PRKACG [cytosol]
(Homo sapiens)
Participates
as a member of
PKA catalytic subunits, PKG type I [cytosol] (Homo sapiens)
as an output of
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
as a component of
PRKAR2A-PKA type II [cytosol] (Homo sapiens)
PKA tetramer [cytosol] (Homo sapiens)
as an input of
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
This entity regulates
Positively
ER calcium channels open in response to activated PKA
(Homo sapiens)
Potassium voltage-gated channels close in reponse to PKA
(Homo sapiens)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
(Homo sapiens)
Inferred To
PKA catalytic subunit [cytosol]
(Danio rerio)
PKA catalytic subunit [cytosol]
(Dictyostelium discoideum)
PKA catalytic subunit [cytosol]
(Drosophila melanogaster)
PKA catalytic subunit [cytosol]
(Mus musculus)
PKA catalytic subunit [cytosol]
(Plasmodium falciparum)
PKA catalytic subunit [cytosol]
(Rattus norvegicus)
PKA catalytic subunit [cytosol]
(Saccharomyces cerevisiae)
PKA catalytic subunit [cytosol]
(Xenopus tropicalis)
PRKACA [cytosol]
(Bos taurus)
PRKACA [cytosol]
(Caenorhabditis elegans)
PRKACA [cytosol]
(Canis familiaris)
PRKACA [cytosol]
(Schizosaccharomyces pombe)
PRKACA [cytosol]
(Sus scrofa)
PRKACB [cytosol]
(Gallus gallus)
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