Vasopressin regulates renal water homeostasis via Aquaporins

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.

Literature References
PubMed ID Title Journal Year
11773613 Aquaporins in the kidney: from molecules to medicine

Marples, D, Knepper, MA, Kwon, TH, Nielsen, S, Agre, P, Fr√łkiaer, J

Physiol Rev 2002
17222168 Regulation and dysregulation of aquaporins in water balance disorders

Kwon, TH, Nielsen, S, Agre, P, Fr√łkiaer, J

J Intern Med 2007
18566824 Localization and trafficking of aquaporin 2 in the kidney

Ablimit, A, Takata, K, Hasegawa, T, Matsuzaki, T, Tajika, Y

Histochem Cell Biol 2008
15924268 The renal plumbing system: aquaporin water channels

Nejsum, LN

Cell Mol Life Sci 2005
19096775 Regulation of aquaporin-2 trafficking

Beulshausen, S, Klussmann, E, Tamma, G, Rosenthal, W, Valenti, G, Nedvetsky, PI

Handb Exp Pharmacol 2009
Event Information
Go Biological Process
Orthologous Events
Cite Us!