Reactome | Vasopressin regulates renal water homeostasis via Aquaporins

Vasopressin regulates renal water homeostasis via Aquaporins

Stable Identifier

R-HSA-432040

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Vasopressin regulates renal water homeostasis via Aquaporins

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In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
19096775	Regulation of aquaporin-2 trafficking Nedvetsky, PI, Tamma, G, Beulshausen, S, Valenti, G, Rosenthal, W, Klussmann, E	Handb Exp Pharmacol	2009
15924268	The renal plumbing system: aquaporin water channels Nejsum, LN	Cell Mol Life Sci	2005
18566824	Localization and trafficking of aquaporin 2 in the kidney Takata, K, Matsuzaki, T, Tajika, Y, Ablimit, A, Hasegawa, T	Histochem Cell Biol	2008
17222168	Regulation and dysregulation of aquaporins in water balance disorders Nielsen, S, Kwon, TH, Frøkiaer, J, Agre, P	J Intern Med	2007
11773613	Aquaporins in the kidney: from molecules to medicine Nielsen, S, Frøkiaer, J, Marples, D, Kwon, TH, Agre, P, Knepper, MA	Physiol Rev	2002