Transport of glycerol from adipocytes to the liver by Aquaporins

Stable Identifier
R-HSA-432030
Type
Pathway
Species
Homo sapiens
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Triglycerides stored in adipocytes are hydrolyzed to yield fatty acids and glycerol. The glycerol is passively transported out of the adipocyte and into the bloodstream by Aquaporin-7 (AQP7) located in the plasma membrane of adipocytes. Glycerol in the bloodstream is passively transported into liver cells by AQP9 located in the plasma membrane of hepatocytes. Once inside the liver cell the glycerol is a substrate for gluconeogenesis.

Literature References
PubMed ID Title Journal Year
16764946 Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways

Frühbeck, G, Catalán, V, Gómez-Ambrosi, J, Rodriguez, A

Trends Pharmacol Sci 2006
19096781 Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity

Maeda, N, Hibuse, T, Funahashi, T

Handb Exp Pharmacol 2009
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