Aquaporin-9 passively transports glycerol into cell

Stable Identifier
R-HSA-432049
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aquaporin-9 (AQP9) passively transports water, glycerol, urea, and some other small neutral solutes across the plasma membrane according to the osmotic gradient. AQP9 is expressed in the sinusoidal plasma membrane in the liver facing the portal vein where it is believed to be responsible for glycerol uptake as part of gluconeogenesis. AQP9 is also expressed in glia, neurons, and peripheral leukocytes.

Literature References
PubMed ID Title Journal Year
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

Padma, S, Smeltz, AM, Banks, PM, Iannitti, DA, McKillop, IH

HPB (Oxford) 2009
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ohgusu, Y, Ohta, KY, Ishii, M, Katano, T, Urano, K, Watanabe, J, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Elkjaer, M, Vajda, Z, Nejsum, LN, Kwon, T, Jensen, UB, Amiry-Moghaddam, M, Fr√łkiaer, J, Nielsen, S

Biochem Biophys Res Commun 2000
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Tsukaguchi, H, Weremowicz, S, Morton, CC, Hediger, MA

Am J Physiol 1999
17961083 A current view of the mammalian aquaglyceroporins

Rojek, A, Praetorius, J, Fr√łkiaer, J, Nielsen, S, Fenton, RA

Annu Rev Physiol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycerol channel activity of AQP9 tetramer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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