Aquaporin-9 passively transports glycerol into cell

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-9 (AQP9) passively transports water, glycerol, urea, and some other small neutral solutes across the plasma membrane according to the osmotic gradient. AQP9 is expressed in the sinusoidal plasma membrane in the liver facing the portal vein where it is believed to be responsible for glycerol uptake as part of gluconeogenesis. AQP9 is also expressed in glia, neurons, and peripheral leukocytes.

Literature References
PubMed ID Title Journal Year
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ishii, M, Ohta, KY, Watanabe, J, Katano, T, Ohgusu, Y, Urano, K, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

McKillop, IH, Iannitti, DA, Banks, PM, Smeltz, AM, Padma, S

HPB (Oxford) 2009
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Kwon, T, Vajda, Z, Amiry-Moghaddam, M, Jensen, UB, Nejsum, LN, Elkjaer, M, Nielsen, S, Fr√łkiaer, J

Biochem Biophys Res Commun 2000
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Weremowicz, S, Hediger, MA, Tsukaguchi, H, Morton, CC

Am J Physiol 1999
17961083 A current view of the mammalian aquaglyceroporins

Praetorius, J, Rojek, A, Fenton, RA, Nielsen, S, Fr√łkiaer, J

Annu Rev Physiol 2008
Catalyst Activity

glycerol channel activity of AQP9 tetramer [plasma membrane]

Orthologous Events
Cross References
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