Aquaporin-7 (AQP7) passively transports glycerol and water across the plasma membrane according to the osmotic gradient. AQP7 is expressed in adipocytes under the direct control of the PPARG and RXRA nuclear receptors. Expression of AQP7 correlates with release of glycerol from adipocytes. AQP7 is seen to translocate from the nuclear periphery to the plasma membrane during adrenaline-stimulated lipolysis. In rat AQP7 also transports urea.
Ishida, N, Matsuzawa, Y, Mita, S, Matsubara, K, Okubo, K, Ohno, I, Kuriyama, H, Kawamoto, S
Tichansky, DS, Bahouth, SW, Madan, AK, Buehrer, B, Fain, JN
Kondo, H, Nakamura, T, Kishida, K, Kuriyama, H, Kihara, S, Shimomura, I, Kurachi, Y, Maeda, N, Makino, Y, Nagaretani, H, Nishizawa, H, Matsuda, M, Matsuzawa, Y, Funahashi, T
Marrades, MP, Martinez, JA, Milagro, FI, Moreno-Aliaga, MJ
Praetorius, J, Rojek, A, Fenton, RA, Nielsen, S, Frøkiaer, J
glycerol channel activity of AQP7 tetramer [plasma membrane]
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