Aquaporin-7 passively transports glycerol out of cell

Stable Identifier
R-HSA-432074
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aquaporin-7 (AQP7) passively transports glycerol and water across the plasma membrane according to the osmotic gradient. AQP7 is expressed in adipocytes under the direct control of the PPARG and RXRA nuclear receptors. Expression of AQP7 correlates with release of glycerol from adipocytes. AQP7 is seen to translocate from the nuclear periphery to the plasma membrane during adrenaline-stimulated lipolysis. In rat AQP7 also transports urea.

Literature References
PubMed ID Title Journal Year
18555844 Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue

Fain, JN, Buehrer, B, Bahouth, SW, Tichansky, DS, Madan, AK

Metabolism 2008
9405233 Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability

Kuriyama, H, Kawamoto, S, Ishida, N, Ohno, I, Mita, S, Matsuzawa, Y, Matsubara, K, Okubo, K

Biochem Biophys Res Commun 1997
11952783 Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation

Kondo, H, Shimomura, I, Kishida, K, Kuriyama, H, Makino, Y, Nishizawa, H, Matsuda, M, Maeda, N, Nagaretani, H, Kihara, S, Kurachi, Y, Nakamura, T, Funahashi, T, Matsuzawa, Y

Eur J Biochem 2002
16325777 Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers

Marrades, MP, Milagro, FI, Martinez, JA, Moreno-Aliaga, MJ

Biochem Biophys Res Commun 2006
17961083 A current view of the mammalian aquaglyceroporins

Rojek, A, Praetorius, J, Fr√łkiaer, J, Nielsen, S, Fenton, RA

Annu Rev Physiol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycerol channel activity of AQP7 tetramer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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