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GABBR2 [plasma membrane]
Stable Identifier
R-HSA-420747
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Gamma-aminobutyric acid type B receptor subunit 2, GABR2_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
G protein gated Potassium channels (Homo sapiens)
Activation of G protein gated Potassium channels (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABA B receptor activation (Homo sapiens)
Activation of GABAB receptors (Homo sapiens)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
Activation of GIRK/Kir3 Channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Association of GABA B receptor with G protein beta-gamma subunits (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABA B receptor G-protein beta-gamma complex [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABAB heterodimeric receptor binds GABA (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
GABAB heterodimeric receptor binds GABA (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
GABBR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75899 GABBR2
Gene Names
GABBR2, GPR51, GPRC3B
Chain
signal peptide:1-41, chain:42-941
Reference Genes
BioGPS Gene:9568 GABBR2
COSMIC (genes):GABBR2 GABBR2
CTD Gene:9568 GABBR2
dbSNP Gene:9568 GABBR2
ENSEMBL:ENSG00000136928 GABBR2
HGNC:4507 GABBR2
KEGG:hsa:9568 GABBR2
Monarch:9568 GABBR2
NCBI Gene:9568 GABBR2
OMIM:607340 GABBR2
UCSC:O75899 GABBR2
Reference Transcript
RefSeq:NM_005458.7 GABBR2
Other Identifiers
11726427_at
11745468_a_at
17096493
209990_PM_s_at
209990_s_at
209991_PM_x_at
209991_x_at
211679_PM_x_at
211679_x_at
217077_PM_s_at
217077_s_at
3217243
3217244
3217245
3217246
3217247
3217248
3217249
3217252
3217254
3217255
3217256
3217257
3217258
3217261
3217276
3217277
3217278
3217280
3217281
3217283
3217284
3217287
3217295
3217296
3217298
3217299
3217303
3217312
3217313
3217314
3217318
3217325
3217345
3217346
3217347
3217348
3217349
3217350
3217351
3217352
33764_at
3435889
7895165
8162777
90018_at
9568
A_23_P112275
A_33_P3406493
GE61390
GE809037
GE81513
GO:0004888
GO:0004930
GO:0004965
GO:0005515
GO:0005737
GO:0005886
GO:0007186
GO:0007193
GO:0007194
GO:0007214
GO:0007268
GO:0016020
GO:0023052
GO:0038039
GO:0043005
GO:0045202
GO:0045211
GO:0046982
GO:0051932
GO:0060089
GO:0150099
GO:1902710
GO:1902712
HMNXSV003028650
Hs.198612.1.A1_3p_s_at
ILMN_1660718
PH_hs_0011690
TC09001406.hg
g3719225_3p_s_at
Participates
as a component of
GABBR1:GABBR2 [plasma membrane] (Homo sapiens)
Inferred To
Gabbr2 [plasma membrane]
(Mus musculus)
Gabbr2 [plasma membrane]
(Rattus norvegicus)
GABA-B-R2 [plasma membrane]
(Drosophila melanogaster)
gabbr2 [plasma membrane]
(Xenopus tropicalis)
grlE [plasma membrane]
(Dictyostelium discoideum)
GABBR2 [plasma membrane]
(Bos taurus)
GABBR2 [plasma membrane]
(Canis familiaris)
GABBR2 [plasma membrane]
(Gallus gallus)
GABBR2 [plasma membrane]
(Sus scrofa)
gbb-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_005449.5
Guide to Pharmacology - Targets
241
OpenTargets
ENSG00000136928
ENSEMBL
ENST00000259455
,
ENSP00000259455
HPA
ENSG00000136928-GABBR2
PRO
O75899
Pharos - Targets
O75899
Orphanet
GABBR2
GlyGen
O75899
PDB
4PAS
,
6WIV
,
4MRM
,
4MS3
,
7CUM
,
4MR7
,
4MR8
,
6OCP
,
6W2X
,
4MS1
,
4MS4
,
7EB2
,
4MQE
,
4F11
,
4MQF
,
4F12
,
4MR9
,
7CA3
,
7CA5
,
7C7S
,
6VJM
,
6UO8
,
6UO9
,
6UOA
,
7C7Q
,
6M8R
HMDB Protein
HMDBP07707
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.611
4
UniProt:Q86UR5 RIMS1
1
RIMS1 [cytosol]
(R-HSA-210407)
0.499
2
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