Reactome | Gabbr2 [plasma membrane]

Gabbr2 [plasma membrane]

Stable Identifier

R-RNO-420747

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

GABBR2, O88871

Locations in the PathwayBrowser

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Neuronal System (Rattus norvegicus)

- Potassium Channels (Rattus norvegicus)
  - Inwardly rectifying K+ channels (Rattus norvegicus)
    - G protein gated Potassium channels (Rattus norvegicus)
      - Activation of G protein gated Potassium channels (Rattus norvegicus)
        
        Activation of GIRK/Kir3 Channels (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - GABA receptor activation (Rattus norvegicus)
      - GABA B receptor activation (Rattus norvegicus)
        
        Activation of GABAB receptors (Rattus norvegicus)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Rattus norvegicus)
        
        Activation of GIRK/Kir3 Channels (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABAB heterodimeric receptor binds GABA (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
      - GABAB heterodimeric receptor binds GABA (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2:GABA [plasma membrane] (Rattus norvegicus)
        
        GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)
        
        Gabbr2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O88871

Gene Names

Gabbr2

Reference Genes

BioGPS Gene:83633 Gabbr2

ENSEMBL:ENSRNOG00000008431

KEGG:rno:83633 Gabbr2

Monarch:83633 Gabbr2

NCBI Gene:83633 Gabbr2

UCSC:O88871 Gabbr2

Reference Transcript

RefSeq:NM_031802.2 Gabbr2

Participates

as a component of

GABBR1:GABBR2 [plasma membrane] (Rattus norvegicus)

Inferred From

GABBR2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_113990.2

PRO

O88871

GlyGen

O88871

RGD

619864

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