Reactome | CASR [plasma membrane]

CASR [plasma membrane]

Stable Identifier

R-HSA-420719

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular calcium-sensing receptor, CASR_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P41180 CASR

Gene Names

CASR, GPRC2A, PCAR1

Chain

signal peptide:1-19, chain:20-1078

Reference Genes

BioGPS Gene:846 CASR

COSMIC (genes):CASR CASR

CTD Gene:846 CASR

dbSNP Gene:846 CASR

ENSEMBL:ENSG00000036828 CASR

ENSEMBL_homo_sapiens_GENE:ENSG00000036828.17 CASR

HGNC:1514 CASR

KEGG Gene (Homo sapiens):846 CASR

Monarch:846 CASR

NCBI Gene:846 CASR

OMIM:601199 CASR

UCSC:P41180 CASR

Reference Transcript

Other Identifiers

11726226_a_at

11726227_a_at

16944632

210577_PM_at

210577_at

211384_PM_s_at

211384_s_at

240886_PM_at

240886_at

242744_3p_s_at

242744_PM_s_at

242744_s_at

244330_PM_at

244330_at

2638825

2638826

2638827

2638835

2638836

2638837

2638839

2638840

2638841

2638842

2638843

2638844

2638845

2638846

2638851

2638852

2638853

2638854

2638855

2638856

2638857

2638858

2638859

2638860

2638861

38958_at

38959_s_at

53307_at

76633_at

8082046

82476_at

82744_s_at

846

A_23_P29719

A_33_P3280646

D50855_s_at

GE59003

GE630398

GE715667

GE736475

GO:0001503

GO:0002931

GO:0003013

GO:0003824

GO:0004435

GO:0004930

GO:0005178

GO:0005509

GO:0005513

GO:0005515

GO:0005886

GO:0006874

GO:0007165

GO:0007186

GO:0007193

GO:0007200

GO:0007254

GO:0007635

GO:0008284

GO:0009653

GO:0009986

GO:0010038

GO:0010628

GO:0014070

GO:0016020

GO:0016323

GO:0016324

GO:0016597

GO:0016787

GO:0019901

GO:0023052

GO:0030424

GO:0032024

GO:0032782

GO:0035729

GO:0042311

GO:0042802

GO:0042803

GO:0043025

GO:0043679

GO:0044325

GO:0045907

GO:0046872

GO:0048754

GO:0048856

GO:0050896

GO:0050927

GO:0051592

GO:0051924

GO:0055065

GO:0055085

GO:0060089

GO:0060613

GO:0070374

GO:0070509

GO:0071305

GO:0071333

GO:0071404

GO:0071456

GO:0071774

GO:0090280

GO:1901653

GO:1902476

HMNXSV003033640

Hs.124178.0.A1_3p_at

Hs.168746.0.A1_3p_s_at

Hs.55327.0.A1_3p_at

ILMN_1767711

PH_hs_0028914

TC03000627.hg

U20759_s_at

U20760_at

g683746_3p_at

g904209_3p_a_at

Participates

as a component of

as an input of

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

Inferred To

CASR [plasma membrane] (Bos taurus)

CASR [plasma membrane] (Canis familiaris)

CASR [plasma membrane] (Gallus gallus)

CASR [plasma membrane] (Mus musculus)

CASR [plasma membrane] (Rattus norvegicus)

CASR [plasma membrane] (Sus scrofa)

casr [plasma membrane] (Xenopus tropicalis)

Homologues of CASR [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_016862813.1, NP_000379.2, NP_001171536.1, XP_006713852.1, XP_016862814.1

ZINC - World Drugs

CASR_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000036828

ZINC - FDA approved

CASR_HUMAN

ZINC - Substances

CASR_HUMAN

ZINC target

P41180

PRO

P41180

PDB

7DTU, 5FBK, 7M3J, 7SIL, 7E6T, 8SZI, 7SIN, 5K5S, 7DTW, 7M3E, 8SZG, 5FBH, 7E6U, 8SZF, 7SIM, 7DTT, 8WPG, 7M3G, 8SZH, 7M3F, 8WPU, 7DTV, 5K5T

ZINC - Investigational

CASR_HUMAN

HPA

ENSG00000036828-CASR

GeneCards

P41180

Ensembl

ENSP00000492190, ENSP00000420194, ENST00000638421, ENST00000639785, ENSP00000491584, ENST00000498619, ENSG00000036828

Pharos - Targets

P41180

ZINC - Predictions - Purchasable

CASR_HUMAN

Orphanet

15401

HMDB Protein

HMDBP02718

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [Golgi membrane] (R-HSA-6808804) TMED2 [transport vesicle] (R-HSA-6808806)	0.508	3

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