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Class C/3 (Metabotropic glutamate/pheromone receptors)
Stable Identifier
R-HSA-420499
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
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The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.
Literature References
PubMed ID
Title
Journal
Year
17266540
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors
Jensen, AA
,
Wellendorph, P
,
Brauner-Osborne, H
Curr Drug Targets
2007
12782243
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Prézeau, L
,
Galvez, T
,
Pin, JP
Pharmacol Ther
2003
Participants
Events
Metabotropic glutamate receptors bind glutamate
(Homo sapiens)
CASR binds Ca2+
(Homo sapiens)
CASR binds CASR agonists
(Homo sapiens)
GPRC6A can bind L-alpha amino acids and calcium
(Homo sapiens)
GABAB heterodimeric receptor binds GABA
(Homo sapiens)
T1R1/T1R3 dimer is the umami taste receptor
(Homo sapiens)
T1R2/T1R3 dimer is a sweet taste receptor
(Homo sapiens)
T2Rs bind bitter-tasting compounds
(Homo sapiens)
Participates
as an event of
GPCR ligand binding (Homo sapiens)
Orthologous Events
Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Caenorhabditis elegans)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Danio rerio)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Dictyostelium discoideum)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Drosophila melanogaster)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Gallus gallus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Mus musculus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Rattus norvegicus)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Sus scrofa)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Xenopus tropicalis)
Authored
Jassal, B (2009-05-12)
Reviewed
D'Eustachio, P (2009-05-29)
Created
Jassal, B (2009-05-12)
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