Reactome | FANCD2 binds FANCI

FANCD2 binds FANCI

Stable Identifier

R-HSA-6785594

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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FANCD2 binds FANCI, forming the ID2 complex (Yuan et al. 2009, Joo et al. 2011). The ID2 complex plays an important role in the repair of DNA interstrand crosslinks (the Fanconi anemia pathway).

Literature References

PubMed ID	Title	Journal	Year
19561358	FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures Zhang, Y, Zhou, W, Yuan, F, El Hokayem, J	J. Biol. Chem.	2009
21764741	Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway Elledge, SJ, Joo, W, Xu, G, Buzovetsky, O, Persky, NS, Pavletich, NP, Rudge, DG, Smogorzewska, A	Science	2011