FANCD2 binds FANCI

Stable Identifier
R-HSA-6785594
Type
Reaction
Species
Homo sapiens
Compartment
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FANCD2 binds FANCI, forming the ID2 complex (Yuan et al. 2009, Joo et al. 2011). The ID2 complex plays an important role in the repair of DNA interstrand crosslinks (the Fanconi anemia pathway).

Literature References
PubMed ID Title Journal Year
19561358 FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures

Zhang, Y, Zhou, W, Yuan, F, El Hokayem, J

J. Biol. Chem. 2009
21764741 Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway

Elledge, SJ, Joo, W, Xu, G, Buzovetsky, O, Persky, NS, Pavletich, NP, Rudge, DG, Smogorzewska, A

Science 2011
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