Reactome | LPAR3 [plasma membrane]

LPAR3 [plasma membrane]

Stable Identifier

R-HSA-419379

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 3, LPAR3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBY5 LPAR3

Gene Names

LPAR3, EDG7, LPA3

Chain

chain:1-353

Reference Genes

BioGPS Gene:23566 LPAR3

COSMIC (genes):LPAR3 LPAR3

CTD Gene:23566 LPAR3

dbSNP Gene:23566 LPAR3

ENSEMBL:ENSG00000171517 LPAR3

ENSEMBL_homo_sapiens_GENE:ENSG00000171517.6 LPAR3

HGNC:14298 LPAR3

KEGG Gene (Homo sapiens):23566 LPAR3

Monarch:23566 LPAR3

NCBI Gene:23566 LPAR3

OMIM:605106 LPAR3

UCSC:Q9UBY5 LPAR3

Reference Transcript

RefSeq:NM_012152.2 LPAR3

Other Identifiers

11735220_at

16688992

220816_PM_at

220816_at

231192_PM_at

231192_at

23566

2420614

2420616

2420617

2420618

2420619

2420620

2420621

2420633

2420634

2420635

2420638

2420639

49819_at

7917276

A_23_P35035

A_23_P436048

A_32_P108666

GE555043

GE61188

GO:0004930

GO:0005515

GO:0005737

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0007204

GO:0007268

GO:0008289

GO:0010467

GO:0016020

GO:0019222

GO:0023052

GO:0030154

GO:0030424

GO:0032060

GO:0043410

GO:0045202

GO:0048668

GO:0048672

GO:0048856

GO:0060089

GO:0070915

HMNXSV003038526

HMNXSV003041860

Hs.99083.0.A1_3p_at

ILMN_1709719

PH_hs_0013572

PH_hs_0038075

TC01002823.hg

g6912347_3p_at

Participates

as a member of

LPAR1,2,3,5 [plasma membrane] (Homo sapiens)

Inferred To

lpar3 [plasma membrane] (Danio rerio)

lpar3 [plasma membrane] (Xenopus tropicalis)

LPAR3 [plasma membrane] (Bos taurus)

LPAR3 [plasma membrane] (Canis familiaris)

LPAR3 [plasma membrane] (Gallus gallus)

LPAR3 [plasma membrane] (Sus scrofa)

Lpar3 [plasma membrane] (Mus musculus)

Lpar3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_036284.1

Guide to Pharmacology - Targets

274

OpenTargets

ENSG00000171517

ZINC - Substances

LPAR3_HUMAN

ZINC - Biogenic

LPAR3_HUMAN

ZINC target

Q9UBY5

PRO

Q9UBY5

ZINC - Metabolites

LPAR3_HUMAN

GeneCards

Q9UBY5

HPA

ENSG00000171517-LPAR3

Ensembl

ENSP00000359643, ENST00000370611, ENSG00000171517, ENST00000440886, ENSP00000395389

Pharos - Targets

Q9UBY5

ZINC - Predictions - Purchasable

LPAR3_HUMAN

HMDB Protein

HMDBP07310

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	5
UniProt:Q8N183 NDUFAF2	1	NDUFAF2 [mitochondrial inner membrane] (R-HSA-5689129)	0.556	3
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q8NHU3 SGMS2	1	2xPalmC-SGMS2 [plasma membrane] (R-HSA-429775)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3