Reactome | LPAR3 [plasma membrane]

LPAR3

Stable Identifier

R-HSA-419379

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Lysophosphatidic acid receptor 3, LPAR3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Lysosphingolipid and LPA receptors (Homo sapiens)
        
        LPA-binding receptors bind LPA (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5:LPA [plasma membrane] (Homo sapiens)
        
        LPAR1,2,3,5 [plasma membrane] (Homo sapiens)
        
        LPAR3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBY5 LPAR3

Gene Names

LPAR3, EDG7, LPA3

Chain

chain:1-353

Reference Genes

BioGPS Gene:23566 LPAR3

COSMIC (genes):LPAR3 LPAR3

CTD Gene:23566 LPAR3

dbSNP Gene:23566 LPAR3

ENSEMBL:ENSG00000171517 LPAR3

HGNC:14298 LPAR3

KEGG Gene (Homo sapiens):hsa:23566 LPAR3

Monarch:23566 LPAR3

NCBI Gene:23566 LPAR3

OMIM:605106 LPAR3

UCSC:Q9UBY5 LPAR3

Reference Transcript

RefSeq:NM_012152.2 LPAR3

Other Identifiers

0004810484

11735220_at

13421

16688992

220816_at

231192_at

23566

2420617

2420618

2420619

2420620

2420621

2420633

2420634

2420635

2420638

2420639

49819_at

7917276

A_23_P35035

A_23_P436048

A_32_P108666

AAD56311

AAF00530

AAI26269

AAI26271

AAP84360

AF127138

AF186380

AY322547

BC126268

BC126270

CCDS700

ENSG00000171517

ENSP00000359643

ENSP00000395389

ENST00000370611

ENST00000440886

EntrezGene:23566

g6912347_3p_at

GE555043

GE61188

GO:0000187

GO:0000902

GO:0001965

GO:0003674

GO:0004871

GO:0004930

GO:0005543

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0007165

GO:0007186

GO:0007187

GO:0007204

GO:0007267

GO:0007268

GO:0008150

GO:0008289

GO:0016020

GO:0016021

GO:0022607

GO:0030154

GO:0030424

GO:0032060

GO:0040007

GO:0042592

GO:0043167

GO:0043410

GO:0048672

GO:0048856

GO:0051482

GO:0051928

GO:0070915

HGNC:14298

HPA013421

Hs.99083.0.A1_3p_at

ILMN_1709719

ILMN_3243253

IPR000276

IPR004065

IPR005385

IPR017452

LPAR3

LPAR3-201

LPAR3-202

MIM:605106

NM_012152

NP_036284

PF00001

PH_hs_0013572

PH_hs_0038075

PR00237

PR01527

PR01560

SM01381

TC01002823.hg

uc001dkl.3

uc009wcj.2

UPI000003CAC0

Participant Of

hasMember

LPAR1,2,3,5 [plasma membrane]

Inferred To

LPAR3 [plasma membrane] (Bos taurus)

LPAR3 [plasma membrane] (Canis familiaris)

LPAR3 [plasma membrane] (Danio rerio)

LPAR3 [plasma membrane] (Gallus gallus)

LPAR3 [plasma membrane] (Mus musculus)

LPAR3 [plasma membrane] (Rattus norvegicus)

LPAR3 [plasma membrane] (Sus scrofa)

LPAR3 [plasma membrane] (Taeniopygia guttata)

LPAR3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_036284.1

ZINC - Metabolites

LPAR3_HUMAN

ZINC - Substances

LPAR3_HUMAN

GeneCards

Q9UBY5

ZINC target

Q9UBY5

ZINC - Biogenic

LPAR3_HUMAN

PRO

Q9UBY5

ZINC - Predictions - Purchasable

LPAR3_HUMAN

HMDB Protein

HMDBP07310

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.488	2
UniProt:Q8N183 NDUFAF2	1	NDUFAF2 [mitochondrial inner membrane] (R-HSA-5689129)	0.488	2
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.488	2
UniProt:Q3SXY8 ARL13B	1	ARL13B [cilium] (R-HSA-5618181)	0.488	2
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.488	2
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.488	2
UniProt:Q8NHU3 SGMS2	1	2xPalmC-SGMS2 [plasma membrane] (R-HSA-429775)	0.488	2