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PTAFR [plasma membrane]
Stable Identifier
R-HSA-419376
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PAF receptor, Platelet-activating factor receptor, PTAFR_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
PAF receptor binds platelet activating factor (Homo sapiens)
PAF receptor:PAF [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
PTAFR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25105 PTAFR
Gene Names
PTAFR, PAFR
Chain
chain:1-342
Reference Genes
BioGPS Gene:5724 PTAFR
COSMIC (genes):PTAFR PTAFR
CTD Gene:5724 PTAFR
dbSNP Gene:5724 PTAFR
ENSEMBL:ENSG00000169403 PTAFR
HGNC:9582 PTAFR
KEGG:hsa:5724 PTAFR
Monarch:5724 PTAFR
NCBI Gene:5724 PTAFR
OMIM:173393 PTAFR
UCSC:P25105 PTAFR
Reference Transcript
RefSeq:NM_001164722.2 PTAFR
RefSeq:NM_000952.4 PTAFR
RefSeq:NM_001164721.1 PTAFR
RefSeq:NM_001164723.2 PTAFR
Other Identifiers
11732180_a_at
11732181_x_at
16684144
206278_3p_at
206278_PM_at
206278_at
211661_PM_x_at
211661_x_at
227184_PM_at
227184_at
2403445
2403447
2403448
2403449
2403450
2403454
2403463
341_at
47057_at
5724
7914184
A_23_P51926
A_24_P102821
A_33_P3393537
D10202_at
GE57041
GE863214
GO:0001530
GO:0001875
GO:0002376
GO:0002693
GO:0004930
GO:0004992
GO:0005515
GO:0005543
GO:0005886
GO:0006355
GO:0006357
GO:0006935
GO:0006954
GO:0006955
GO:0007186
GO:0007200
GO:0007567
GO:0008289
GO:0009609
GO:0016020
GO:0016192
GO:0022414
GO:0030667
GO:0031663
GO:0032496
GO:0032755
GO:0032760
GO:0032959
GO:0035589
GO:0043315
GO:0045028
GO:0045056
GO:0045727
GO:0045776
GO:0045987
GO:0046683
GO:0048661
GO:0051019
GO:0060089
GO:0060732
GO:0070821
GO:0071258
GO:0071320
GO:0071398
GO:0071548
GO:1903039
GO:1903238
GO:1904300
GO:1904303
GO:1904306
GO:1904316
GO:1904317
HMNXSV003038721
HMNXSV003043072
Hs.77542.0.A1_3p_at
ILMN_1746836
PH_hs_0000006
TC01002421.hg
TC01005362.hg
g189537_3p_s_at
g219975_3p_at
Participates
as a member of
IL10-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as an input of
PAF receptor binds platelet activating factor (Homo sapiens)
as an output of
Expression of IFNG-stimulated genes (Homo sapiens)
as a component of
PAF receptor:PAF [plasma membrane] (Homo sapiens)
Other forms of this molecule
PTAFR [secretory granule membrane]
PTAFR [tertiary granule membrane]
Inferred To
Ptafr [plasma membrane]
(Mus musculus)
Ptafr [plasma membrane]
(Rattus norvegicus)
PTAFR [plasma membrane]
(Bos taurus)
PTAFR [plasma membrane]
(Canis familiaris)
PTAFR [plasma membrane]
(Gallus gallus)
PTAFR [plasma membrane]
(Sus scrofa)
ptafr [plasma membrane]
(Danio rerio)
ptafr [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000943.1
,
NP_001158193.1
,
NP_001158195.1
,
NP_001158194.1
Guide to Pharmacology - Targets
334
ENSEMBL
ENSP00000442658
,
ENST00000539896
,
ENSP00000301974
,
ENSP00000362965
,
ENST00000373857
,
ENST00000305392
,
ENSG00000169403
OpenTargets
ENSG00000169403
ZINC - Substances
PTAFR_HUMAN
ZINC - Biogenic
PTAFR_HUMAN
ZINC target
P25105
PRO
P25105
GlyGen
P25105
PDB
5ZKP
,
5ZKQ
ZINC - Investigational
PTAFR_HUMAN
GeneCards
PTAFR
HPA
ENSG00000169403-PTAFR
Pharos - Targets
P25105
ZINC - Predictions - Purchasable
PTAFR_HUMAN
HMDB Protein
HMDBP02510
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02686 MBP
1
MBP [cytosol]
(R-HSA-9614770)
0.454
2
UniProt:P04156 PRNP
2
PRNP [plasma membrane]
(R-HSA-375060)
PRNP [cytosol]
(R-HSA-9617597)
0.454
2
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