Reactome | PAF receptor binds platelet activating factor

PAF receptor binds platelet activating factor

Stable Identifier

R-HSA-419351

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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PAF receptor binds platelet activating factor

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Platelet-activating factor (PAF, AGEPC, acetyl-glyceryl-ether-phosphorylcholine) is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. It is an important mediator of bronchoconstriction. It causes platelets to aggregate and blood vessels to dilate so is important to the process of hemostasis. The PAF receptor (Ye RD et al, 1991) shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). The activity of this receptor is mediated by coupling with the G protein alpha q subunit which stimulates PLC-beta which can cleave PIP2 to form secondary messengers (Deo DD et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
14617636	Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells Deo, DD, Bazan, NG, Hunt, JD	J Biol Chem	2004
1656963	Characterization of a human cDNA that encodes a functional receptor for platelet activating factor Ye, RD, Prossnitz, ER, Zou, AH, Cochrane, CG	Biochem Biophys Res Commun	1991