Reactome | Expression of IFNG-stimulated genes

Expression of IFNG-stimulated genes

Stable Identifier

R-HSA-1031716

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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IFN-gamma stimulates gene expression of about 200 genes which include the primary response genes like IRFs, Fc-gamma receptor (FCGR), GBPs (guanylate-binding proteins) and also major histocompatibility complex (MHC) class I and class II molecules, proteins involved in antigen presentation, antiviral proteins like PKR, OAS proteins etc. A wonderful list of most of the IFN-gamma inducible proteins with corresponding literature are mentioned in the review article and the supplementary document by Boehm et al 1997.

Literature References

PubMed ID	Title	Journal	Year
8483949	Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3 Pearse, RN, Feinman, R, Shuai, K, Darnell JE, Jr, Ravetch, JV	Proc Natl Acad Sci U S A	1993
1508672	Transcriptional induction of IFN-gamma-responsive genes is modulated by DNA surrounding the interferon stimulation response element Strehlow, I, Decker, T	Nucleic Acids Res	1992
8530158	Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview Stratowa, C, Audette, M	Immunobiology	1995
8176225	IFN-gamma up-regulates platelet-activating factor receptor gene expression in human monocytes Ouellet, S, Müller, E, Rola-Pleszczynski, M	J Immunol	1994
7530745	Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines Rosenman, SJ, Shrikant, P, Dubb, L, Benveniste, EN, Ransohoff, RM	J Immunol	1995
18362138	Induction of guanylate binding protein 5 by gamma interferon increases susceptibility to Salmonella enterica serovar Typhimurium-induced pyroptosis in RAW 264.7 cells Rupper, AC, Cardelli, JA	Infect Immun	2008
9143706	Cellular responses to interferon-gamma Boehm, U, Klamp, T, Groot, M, Howard, JC	Annu Rev Immunol	1997

Participants

Input

IFNG-regulated genes with GAS promoter elements [nucleoplasm] (Homo sapiens)

Output

Participates

as an event of

Interferon gamma signaling (Homo sapiens)

This event is regulated

Positively by

Regulator

GAF bound to GAS promoter element [nucleoplasm] (Homo sapiens)

Active Unit

p-STAT1 homodimer [nucleoplasm]

Authored

Garapati, P V (2010-07-07)

Reviewed

Abdul-Sater, AA (2010-08-17)

Schindler, C (2010-08-17)

Created

Garapati, P V (2010-11-18)

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