Reactome | FFAR1:FFAR1 ligands [plasma membrane]

FFAR1:FFAR1 ligands [plasma membrane]

Stable Identifier

R-HSA-400420

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FFAR1:fatty acid

Locations in the PathwayBrowser

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General

The Free fatty acid receptor 1 (FFAR1 or GPR40) is located on pancreatic beta cells and binds to medium and long chain fatty acids (fatty acids having more than 12 carbon groups). FFAR1 is a G-protein coupled receptor that is coupled to Gq.

Participants

components

FFAR1 [plasma membrane] (Homo sapiens)
FFAR1 ligands [extracellular region]

Participates

as an output of

FFAR1 binds fatty acids (Homo sapiens)
Receptor FFAR1 binds free fatty acids (Homo sapiens)

as a member of

Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)

This entity regulates

Positively

Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)

Inferred To

FFAR1:FFAR1 ligands [plasma membrane] (Bos taurus)

FFAR1:FFAR1 ligands [plasma membrane] (Canis familiaris)

FFAR1:FFAR1 ligands [plasma membrane] (Mus musculus)

FFAR1:FFAR1 ligands [plasma membrane] (Rattus norvegicus)