FFAR1:FFAR1 ligands

Summation

The Free fatty acid receptor 1 (FFAR1 or GPR40) is located on pancreatic beta cells and binds to medium and long chain fatty acids (fatty acids having more than 12 carbon groups). FFAR1 is a G-protein coupled receptor that is coupled to Gq.

Participants

components

• FFAR1 [plasma membrane] (Homo sapiens)
• FFAR1 ligands [extracellular region]

Participant Of

hasMember

• Ligand:GPCR complexes that activate Gq/11 [plasma membrane]

output

• GPR40 (Free fatty acid receptor 1, FFAR1) binds fatty acids
• Receptor FFAR1 binds free fatty acids

This entity regulates

Positively

• Glucagon-like Peptide 1 is secreted from intestinal L cells
• Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells

Inferred To

FFAR1:FFAR1 ligands [plasma membrane] (Bos taurus)

FFAR1:FFAR1 ligands [plasma membrane] (Canis familiaris)

FFAR1:FFAR1 ligands [plasma membrane] (Danio rerio)

FFAR1:FFAR1 ligands [plasma membrane] (Mus musculus)

FFAR1:FFAR1 ligands [plasma membrane] (Rattus norvegicus)

FFAR1:FFAR1 ligands [plasma membrane] (Xenopus tropicalis)