Reactome | Glucagon-like Peptide 1 is secreted from intestinal L cells

Glucagon-like Peptide 1 is secreted from intestinal L cells

Stable Identifier

R-HSA-383313

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, secretory granule lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Glucagon-like Peptide 1 is secreted from intestinal L cells

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Secretion of GLP-1 from intestinal L-cells is dependent on a rise in cytosolic calcium which, in turn, is stimulated by glucose (requires the GLUT2 glucose transporter), fatty acids (especially monounsaturated fatty acids, requires the GPR120 and GPR40 receptors), insulin, leptin, gastrin-releasing peptide, cholinergic transmitters (requires M1 and M2 muscarinic receptors), amino acids (requires mitogen activated protein kinase pathway), beta-adrenergic transmitters, and peptidergic transmitters. The exact mechanisms controlling secretion have not been elucidated. The G-protein coupled receptor Alpha-Gustducin is present in human intestinal L cells. The sweet taste receptors TIR2 and TIR3 are also detectable. Experiments in mice lacking Alpha-Gustducin show that it is required for stimulation of GLP-1 secretion by glucose.

Literature References

PubMed ID	Title	Journal	Year
17065399	Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases Reimer, RA	J Endocrinol	2006
15619630	Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Hirasawa, A, Awaji, T, Tsumaya, K, Katsuma, S, Yamada, M, Miyazaki, S, Adachi, T, Sugimoto, Y, Tsujimoto, G	Nat Med	2005
19001044	Nutritional regulation of glucagon-like peptide-1 secretion Tolhurst, G, Gribble, FM, Reimann, F	J Physiol	2008
18519800	Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion Steneberg, P, Edfalk, S, Edlund, H	Diabetes	2008
12810581	Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells Anini, Y, Brubaker, PL	Endocrinology	2003
12540594	Role of leptin in the regulation of glucagon-like peptide-1 secretion Anini, Y, Brubaker, PL	Diabetes	2003
11564718	A human cellular model for studying the regulation of glucagon-like peptide-1 secretion Gremlich, S, Macé, K, Darimont, C, Nicolas-Métral, V, Rüegg, UT, Reimer, RA	Endocrinology	2001
14719035	Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2 Anini, Y, Brubaker, PL	Can J Physiol Pharmacol	2003
16219666	Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP Michopoulos, S, Juhaszova, M, Petraki, K, Carlson, O, Egan, JM, Doyle, ME, Theodorakis, MJ	Am J Physiol Endocrinol Metab	2006
17681422	GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion Delzenne, NM, Thorens, B, Drucker, DJ, Cani, PD, Holst, JJ, Burcelin, R, Knauf, C	Mol Cell Endocrinol	2007