Glucagon-like Peptide 1 is secreted from intestinal L cells

Stable Identifier
Reaction [omitted]
Homo sapiens
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Secretion of GLP-1 from intestinal L-cells is dependent on a rise in cytosolic calcium which, in turn, is stimulated by glucose (requires the GLUT2 glucose transporter), fatty acids (especially monounsaturated fatty acids, requires the GPR120 and GPR40 receptors), insulin, leptin, gastrin-releasing peptide, cholinergic transmitters (requires M1 and M2 muscarinic receptors), amino acids (requires mitogen activated protein kinase pathway), beta-adrenergic transmitters, and peptidergic transmitters. The exact mechanisms controlling secretion have not been elucidated.

The G-protein coupled receptor Alpha-Gustducin is present in human intestinal L cells. The sweet taste receptors TIR2 and TIR3 are also detectable. Experiments in mice lacking Alpha-Gustducin show that it is required for stimulation of GLP-1 secretion by glucose.

Literature References
PubMed ID Title Journal Year
17065399 Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases

Reimer, RA

J Endocrinol 2006
15619630 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Hirasawa, A, Awaji, T, Tsumaya, K, Katsuma, S, Yamada, M, Miyazaki, S, Adachi, T, Sugimoto, Y, Tsujimoto, G

Nat Med 2005
19001044 Nutritional regulation of glucagon-like peptide-1 secretion

Tolhurst, G, Gribble, FM, Reimann, F

J Physiol 2008
18519800 Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion

Steneberg, P, Edfalk, S, Edlund, H

Diabetes 2008
12810581 Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells

Anini, Y, Brubaker, PL

Endocrinology 2003
12540594 Role of leptin in the regulation of glucagon-like peptide-1 secretion

Anini, Y, Brubaker, PL

Diabetes 2003
11564718 A human cellular model for studying the regulation of glucagon-like peptide-1 secretion

Gremlich, S, Macé, K, Darimont, C, Nicolas-Métral, V, Rüegg, UT, Reimer, RA

Endocrinology 2001
14719035 Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2

Anini, Y, Brubaker, PL

Can J Physiol Pharmacol 2003
16219666 Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP

Michopoulos, S, Juhaszova, M, Petraki, K, Carlson, O, Egan, JM, Doyle, ME, Theodorakis, MJ

Am J Physiol Endocrinol Metab 2006
17681422 GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion

Delzenne, NM, Thorens, B, Drucker, DJ, Cani, PD, Holst, JJ, Burcelin, R, Knauf, C

Mol Cell Endocrinol 2007
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