Receptor FFAR1 binds free fatty acids

Stable Identifier
R-HSA-444202
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Free fatty acid receptor 1 (FFAR1/GPR40) is activated by many medium-length fatty acids. In recombinant assays the most potent saturated fatty acids had carbon chain lengths of 15-16; the most potent unsaturated fatty acid tested was 5,8,11-Eicosatriynoic Acid (C20).

Literature References
PubMed ID Title Journal Year
12496284 The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

Briscoe, CP, Tadayyon, M, Andrews, JL, Benson, WG, Chambers, JK, Eilert, MM, Ellis, C, Elshourbagy, NA, Goetz, AS, Minnick, DT, Murdock, PR, Sauls HR, Jr, Shabon, U, Spinage, LD, Strum, JC, Szekeres, PG, Tan, KB, Way, JM, Ignar, DM, Wilson, S, Muir, AI

J Biol Chem 2003
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