Reactome | Receptor FFAR1 binds free fatty acids

Receptor FFAR1 binds free fatty acids

Stable Identifier

R-HSA-444202

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Free fatty acid receptor 1 (FFAR1/GPR40) is activated by many medium-length fatty acids. In recombinant assays the most potent saturated fatty acids had carbon chain lengths of 15-16; the most potent unsaturated fatty acid tested was 5,8,11-Eicosatriynoic Acid (C20).

Literature References

PubMed ID	Title	Journal	Year
12496284	The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids Minnick, DT, Ignar, DM, Muir, AI, Strum, JC, Goetz, AS, Elshourbagy, NA, Tadayyon, M, Briscoe, CP, Sauls HR, Jr, Spinage, LD, Eilert, MM, Szekeres, PG, Benson, WG, Shabon, U, Andrews, JL, Tan, KB, Wilson, S, Murdock, PR, Way, JM, Ellis, C, Chambers, JK	J Biol Chem	2003