Reactome | FFAR1 binds fatty acids

FFAR1 binds fatty acids

Stable Identifier

R-HSA-400434

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Free fatty acid receptor 1 (FFAR1), also known as GPR40, is a G-protein coupled receptor located in the plasma membrane of pancreatic beta cells. FFAR1/GPR40 binds medium and long chain free fatty acids (free fatty acids having more than 12 carbon groups).

Literature References

PubMed ID	Title	Journal	Year
16289108	GPR40 gene expression in human pancreas and insulinoma Shimada, Y, Masuzaki, H, Nakao, K, Kawamura, J, Tanaka, T, Fujikura, J, Doi, R, Ebihara, K, Noguchi, M, Fujimoto, K, Imamura, M, Iwakura, H, Komoto, I, Tomita, T, Kawaguchi, Y, Hosoda, K	Biochem Biophys Res Commun	2005
12496284	The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids Minnick, DT, Ignar, DM, Muir, AI, Strum, JC, Goetz, AS, Elshourbagy, NA, Tadayyon, M, Briscoe, CP, Sauls HR, Jr, Spinage, LD, Eilert, MM, Szekeres, PG, Benson, WG, Shabon, U, Andrews, JL, Tan, KB, Wilson, S, Murdock, PR, Way, JM, Ellis, C, Chambers, JK	J Biol Chem	2003
12565875	A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs Olde, B, Flodgren, E, Owman, C, Kotarsky, K, Nilsson, NE	Biochem Biophys Res Commun	2003
12629551	Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Matsumura, F, Shinohara, T, Okubo, S, Tanaka, Y, Komatsu, H, Itoh, Y, Noguchi, Y, Maruyama, M, Kobayashi, M, Kizawa, H, Kawamata, Y, Fujisawa, Y, Hinuma, S, Harada, M, Fujino, M, Uejima, H, Ogi, K, Fujii, R, Hosoya, M, Tanaka, H, Fukusumi, S, Satoh, R	Nature	2003
19758793	G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids Mosca, F, D'Aleo, V, Filipponi, F, Del Guerra, S, Bugliani, M, Lupi, R, Boggi, U, Del Prato, S	Nutr Metab Cardiovasc Dis	2009
18606873	Glycerolipid metabolism and signaling in health and disease Prentki, M, Madiraju, SR	Endocr Rev	2008
19401434	Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice Esaki, R, Kaisho, Y, Nakata, M, Taketomi, S, Yano, T, Ogi, K, Shimakawa, K, Iwachidow, K, Odaka, H, Takeuchi, K, Yasuhara, Y, Nagasumi, K, Tanaka, H	Diabetes	2009
17101212	Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40 Schöfl, C, Schnell, S, Schaefer, M	Mol Cell Endocrinol	2007