CRMPs in Sema3A signaling

Stable Identifier
R-HSA-399956
Type
Pathway
Species
Homo sapiens
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CRMPs in Sema3A signaling
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CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse.

Literature References
PubMed ID Title Journal Year
17607942 The CRMP family of proteins and their role in Sema3A signaling

Schmidt, EF, Strittmatter, SM

Adv Exp Med Biol 2007
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Orthologous Events
CRMPs in Sema3A signaling (Bos taurus)
CRMPs in Sema3A signaling (Caenorhabditis elegans)
CRMPs in Sema3A signaling (Canis familiaris)
CRMPs in Sema3A signaling (Danio rerio)
CRMPs in Sema3A signaling (Mus musculus)
CRMPs in Sema3A signaling (Rattus norvegicus)
CRMPs in Sema3A signaling (Sus scrofa)
CRMPs in Sema3A signaling (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-03-23)