The phosphorylation of CRMPs at Ser522 allows the subsequent phosphorylation of CRMP1, CRMP2 and CRMP4 at Ser518, Thr509, and Thr514 mediated by serine/threonine kinase GSK3beta. Phosphorylation of CRMP by GSK3beta results in decreased CRMP affinity for beta-tubulin and changes in microtubule dynamics.
Schmidt, EF, Strittmatter, SM
Yoshimura, T, Kawano, Y, Arimura, N, Kawabata, S, Kikuchi, A, Kaibuchi, K
Uchida, Y, Ohshima, T, Sasaki, Y, Suzuki, H, Yanai, S, Yamashita, N, Nakamura, F, Takei, K, Ihara, Y, Mikoshiba, K, Kolattukudy, P, Honnorat, J, Goshima, Y
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