Phosphorylation of CRMPs by GSK3beta

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The phosphorylation of CRMPs at Ser522 allows the subsequent phosphorylation of CRMP1, CRMP2 and CRMP4 at Ser518, Thr509, and Thr514 mediated by serine/threonine kinase GSK3beta. Phosphorylation of CRMP by GSK3beta results in decreased CRMP affinity for beta-tubulin and changes in microtubule dynamics.

Literature References
PubMed ID Title Journal Year
17607942 The CRMP family of proteins and their role in Sema3A signaling

Schmidt, EF, Strittmatter, SM

Adv Exp Med Biol 2007
15652488 GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity

Yoshimura, T, Kawano, Y, Arimura, N, Kawabata, S, Kikuchi, A, Kaibuchi, K

Cell 2005
15676027 Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease

Uchida, Y, Ohshima, T, Sasaki, Y, Suzuki, H, Yanai, S, Yamashita, N, Nakamura, F, Takei, K, Ihara, Y, Mikoshiba, K, Kolattukudy, P, Honnorat, J, Goshima, Y

Genes Cells 2005
Participant Of
Catalyst Activity
Catalyst Activity
protein serine/threonine kinase activity of GSK3B [cytosol]
Physical Entity
Orthologous Events
Cite Us!