Phosphorylation of CRMPs by GSK3beta

Stable Identifier
R-HSA-399951
Type
Reaction
Species
Homo sapiens
Compartment
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The phosphorylation of CRMPs at Ser522 allows the subsequent phosphorylation of CRMP1, CRMP2 and CRMP4 at Ser518, Thr509, and Thr514 mediated by serine/threonine kinase GSK3beta. Phosphorylation of CRMP by GSK3beta results in decreased CRMP affinity for beta-tubulin and changes in microtubule dynamics.

Literature References
PubMed ID Title Journal Year
15652488 GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity

Kawano, Y, Yoshimura, T, Kaibuchi, K, Kikuchi, A, Kawabata, S, Arimura, N

Cell 2005
17607942 The CRMP family of proteins and their role in Sema3A signaling

Strittmatter, SM, Schmidt, EF

Adv Exp Med Biol 2007
15676027 Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease

Nakamura, F, Mikoshiba, K, Yanai, S, Uchida, Y, Takei, K, Sasaki, Y, Ihara, Y, Goshima, Y, Honnorat, J, Ohshima, T, Kolattukudy, P, Suzuki, H, Yamashita, N

Genes Cells 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of GSK3B [cytosol]

Orthologous Events
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