Reactome | Phosphorylation of CRMPs by GSK3beta

Phosphorylation of CRMPs by GSK3beta

Stable Identifier

R-HSA-399951

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The phosphorylation of CRMPs at Ser522 allows the subsequent phosphorylation of CRMP1, CRMP2 and CRMP4 at Ser518, Thr509, and Thr514 mediated by serine/threonine kinase GSK3beta. Phosphorylation of CRMP by GSK3beta results in decreased CRMP affinity for beta-tubulin and changes in microtubule dynamics.

Literature References

PubMed ID	Title	Journal	Year
15652488	GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity Kawano, Y, Yoshimura, T, Kaibuchi, K, Kikuchi, A, Kawabata, S, Arimura, N	Cell	2005
17607942	The CRMP family of proteins and their role in Sema3A signaling Strittmatter, SM, Schmidt, EF	Adv Exp Med Biol	2007
15676027	Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease Nakamura, F, Mikoshiba, K, Yanai, S, Uchida, Y, Takei, K, Sasaki, Y, Ihara, Y, Goshima, Y, Honnorat, J, Ohshima, T, Kolattukudy, P, Suzuki, H, Yamashita, N	Genes Cells	2005