Recruitment and activation of Cdk5

Stable Identifier
R-HSA-399946
Type
Reaction
Species
Homo sapiens
Compartment
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Cyclin-dependent kinase 5 (CDK5), a member of the serine/threonine kinase Cdk family, is complexed with p35 a neuron specific activator of Cdk5. The complex CDK5:p35 is required for neurite outgrowth and cortical lamination. CDK5:p35 complex is recruited to the growth cone by associating with active Fyn. FYN promotes the kinase activity of CDK5 by phosphorylating CDK5 on tyrosine residue 15. Activation of CDK5 by FYN via Tyr15 phosphorylation might facilitate suppression of RAC-PAK signaling downstream of PlexinA.

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Participates
Catalyst Activity

protein tyrosine kinase activity of Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane]

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