Phosphorylation of CRMPs by Cdk5

Stable Identifier
Reaction [transition]
Homo sapiens
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Cdk5:p35 complex is associated with Plexin-A through the actived form of Fyn. CRMPs are the downstream substrates for Cdk5. Cdk5 phosphorylates serine 522 of CRMPs. Phosphorylation of CRMPs mediates the Sema3A induced growth cone collapse.
Collapsin response mediator proteins (CRMPs) are five homologous cytosolic phosphoproteins (CRMP1–5) involved in neuronal differentiation and axonal guidance. These members oligomerize and exist as tetramers.

Literature References
PubMed ID Title Journal Year
12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

Nakamura, F, Taniguchi, M, Ohno, S, Uchida, Y, Nakajima, O, Kudo, Y, Sasaki, Y, Kishida, R, Yagi, T, Nakayama, T, Goshima, Y, Ohshima, T, Cheng, C

Neuron 2002
17607942 The CRMP family of proteins and their role in Sema3A signaling

Strittmatter, SM, Schmidt, EF

Adv Exp Med Biol 2007
14685275 Structural bases for CRMP function in plexin-dependent semaphorin3A signaling

Strittmatter, SM, Elhabazi, A, Togashi, H, Schmidt, EF, Burley, SK, Deo, RC

EMBO J 2004
Catalyst Activity

protein serine/threonine kinase activity of Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane]

Orthologous Events
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