Reactome | p-Y-CRMP1 [cytosol]

p-Y-CRMP1 [cytosol]

Stable Identifier

R-HSA-399784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine phosphorylated CRMP-1

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
        
        Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Homo sapiens)
        
        pCRMP's tertramers (Y499) [cytosol] (Homo sapiens)
        
        Fes phosphorylated CRMP's 1-5 [cytosol] (Homo sapiens)
        
        p-Y-CRMP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14194 CRMP1

Gene Names

CRMP1, DPYSL1, ULIP3

Chain

chain:1-572

Reference Genes

BioGPS Gene:1400 CRMP1

COSMIC (genes):CRMP1 CRMP1

CTD Gene:1400 CRMP1

dbSNP Gene:1400 CRMP1

ENSEMBL:ENSG00000072832 CRMP1

HGNC:2365 CRMP1

KEGG Gene (Homo sapiens):1400 CRMP1

Monarch:1400 CRMP1

NCBI Gene:1400 CRMP1

OMIM:602462 CRMP1

UCSC:Q14194 CRMP1

Reference Transcript

Other Identifiers

0006760136

11716501_a_at

11716502_x_at

11716503_a_at

11716504_x_at

1400

16973975

202517_at

2759045

2759046

2759047

2759050

2759052

2759058

2759059

2759061

2759062

2759063

2759064

2759065

2759066

2759068

2759070

2759072

2759073

2759079

2759085

2759086

2759087

2759088

2759089

2759095

2759096

40272_at

8099172

A_23_P132889

A_24_P20506

D78012_at

GE57292

GE86402

GO:0000226

GO:0000902

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006139

GO:0007010

GO:0007399

GO:0007411

GO:0008092

GO:0008150

GO:0010977

GO:0016787

GO:0016810

GO:0030154

GO:0030426

GO:0030496

GO:0031005

GO:0034641

GO:0040011

GO:0042802

GO:0042995

GO:0043204

GO:0043226

GO:0048666

GO:0048856

GO:1904530

HMNXSV003027267

HMNXSV003038360

ILMN_1664502

ILMN_1789541

ILMN_1811405

PH_hs_0009357

TC04000997.hg

g4503050_3p_at

Participates

as a member of

Fes phosphorylated CRMP's 1-5 [cytosol] (Homo sapiens)

Other forms of this molecule

CRMP1 [cytosol]

p-T509,T514,S518,S522-CRMP1 [cytosol]

p-S522-CRMP1 [cytosol]

Inferred To

phospho-dhp-1 [cytosol] (Caenorhabditis elegans)

phospho-dhp-2 [cytosol] (Caenorhabditis elegans)

phospho-unc-33 [cytosol] (Caenorhabditis elegans)

Homologues of p-Y-CRMP1 [cytosol] (Caenorhabditis elegans)

phospho-CRMP [cytosol] (Drosophila melanogaster)

phospho-CRMP1 [cytosol] (Bos taurus)

phospho-CRMP1 [cytosol] (Canis familiaris)

phospho-CRMP1 [cytosol] (Sus scrofa)

phospho-Crmp1 [cytosol] (Mus musculus)

phospho-Crmp1 [cytosol] (Rattus norvegicus)

phospho-crmp1 [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001275591.1, NP_001014809.1, NP_001275590.1, NP_001304.1

OpenTargets

ENSG00000072832

GeneCards

Q14194

HPA

ENSG00000072832-CRMP1

Ensembl

ENST00000397890, ENST00000324989, ENSP00000380987, ENSP00000321606, ENSG00000072832

PRO

Q14194

PDB

4B3Z

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	14
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.635	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.556	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.508	2

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