NADPH regeneration

Stable Identifier
R-HSA-389542
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Pathway
Species
Homo sapiens
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The conversion of isocitrate to 2-oxoglutarate (alpha-ketoglutarate) with the concomitant synthesis of NADPH from NADP+ is thought to play a significant role in supplying NADPH for other reactions in both the cytosol and the peroxisome (Geisbrecht and Gould 1999). The activity of H6PD (Hexose-6-phosphate dehydrogenase) is thought to play a role in maintaining NADP+ : NADPH balance within the endoplasmic reticulum (Zielinska et al. 2011).

Literature References
PubMed ID Title Journal Year
10521434 The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase

Geisbrecht, BV, Gould, SJ

J Biol Chem 1999
21146583 Biochemistry and physiology of hexose-6-phosphate knockout mice

Lavery, GG, Stewart, PM, Zielinska, AE, Walker, EA

Mol. Cell. Endocrinol. 2011
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