Serotonin loaded synaptic vesicle docking and priming

Stable Identifier
Reaction [transition]
Homo sapiens
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Serotonin loaded synaptic vesicles are docked, inside the synapse in the presynaptic cell, close to the plasmamembrane. The docking brings the vesicles in close proximity to the release site to fascilitate the release of serotonin. Some of the molecules involved in the docking process are Munc 18, Rab3a, Rab 3 interacting molecule (RIM). The priming reaction brings docked but unprimed synaptic vesicles into a releaseable pool. Priming involes formation of the trimeric SNARE complex between two plasmamembrane proteins SNAP25 and Syntaxin and vesicular membrane protein, VAMP2.
Literature References
PubMed ID Title Journal Year
9701566 Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells

Olkkonen, VM, Galli, T, Riento, K, Ehnholm, C, Lehtonen, E, Jansson, S

J Cell Sci 1998
15935055 Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

de Vries, KJ, Zalm, R, Südhof, TC, Verhage, M, Toonen, RF

J Neurochem 2005
17989281 Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus

Dai, H, Sun, J, Rizo, J, Südhof, TC, Dulubova, I, Khvotchev, M

J Neurosci 2007
Catalyst Activity

SNARE binding activity of Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane]

Orthologous Events
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