Serotonin loaded synaptic vesicle docking and priming

Stable Identifier
R-HSA-380905
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Serotonin loaded synaptic vesicles are docked, inside the synapse in the presynaptic cell, close to the plasmamembrane. The docking brings the vesicles in close proximity to the release site to fascilitate the release of serotonin. Some of the molecules involved in the docking process are Munc 18, Rab3a, Rab 3 interacting molecule (RIM). The priming reaction brings docked but unprimed synaptic vesicles into a releaseable pool. Priming involes formation of the trimeric SNARE complex between two plasmamembrane proteins SNAP25 and Syntaxin and vesicular membrane protein, VAMP2.

Literature References
PubMed ID Title Journal Year
15935055 Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

Toonen, RF, de Vries, KJ, Zalm, R, Südhof, TC, Verhage, M

J Neurochem 2005
9701566 Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells

Riento, K, Galli, T, Jansson, S, Ehnholm, C, Lehtonen, E, Olkkonen, VM

J Cell Sci 1998
17989281 Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus

Khvotchev, M, Dulubova, I, Sun, J, Dai, H, Rizo, J, Südhof, TC

J Neurosci 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SNARE binding activity of Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane]
Physical Entity
Activity
Orthologous Events
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Created