Reactome | Serotonin loaded synaptic vesicle docking and priming

Serotonin loaded synaptic vesicle docking and priming

Stable Identifier

R-HSA-380905

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, clathrin-sculpted monoamine transport vesicle membrane, cytosol

ReviewStatus

5/5

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Serotonin loaded synaptic vesicle docking and priming

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Serotonin loaded synaptic vesicles are docked, inside the synapse in the presynaptic cell, close to the plasmamembrane. The docking brings the vesicles in close proximity to the release site to fascilitate the release of serotonin. Some of the molecules involved in the docking process are Munc 18, Rab3a, Rab 3 interacting molecule (RIM). The priming reaction brings docked but unprimed synaptic vesicles into a releaseable pool. Priming involes formation of the trimeric SNARE complex between two plasmamembrane proteins SNAP25 and Syntaxin and vesicular membrane protein, VAMP2.

Literature References

PubMed ID	Title	Journal	Year
9701566	Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells Riento, K, Galli, T, Jansson, S, Ehnholm, C, Lehtonen, E, Olkkonen, VM	J Cell Sci	1998
15935055	Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation Toonen, RF, de Vries, KJ, Zalm, R, Südhof, TC, Verhage, M	J Neurochem	2005
17989281	Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus Khvotchev, M, Dulubova, I, Sun, J, Dai, H, Rizo, J, Südhof, TC	J Neurosci	2007