Serotonin Neurotransmitter Release Cycle

Stable Identifier
R-HSA-181429
Type
Pathway
Species
Homo sapiens
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Serotonin Neurotransmitter Release Cycle
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Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse.

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Orthologous Events
Serotonin Neurotransmitter Release Cycle (Caenorhabditis elegans)
Serotonin Neurotransmitter Release Cycle (Canis familiaris)
Serotonin Neurotransmitter Release Cycle (Danio rerio)
Serotonin Neurotransmitter Release Cycle (Drosophila melanogaster)
Serotonin Neurotransmitter Release Cycle (Gallus gallus)
Serotonin Neurotransmitter Release Cycle (Mus musculus)
Serotonin Neurotransmitter Release Cycle (Rattus norvegicus)
Serotonin Neurotransmitter Release Cycle (Schizosaccharomyces pombe)
Serotonin Neurotransmitter Release Cycle (Sus scrofa)
Authored
Mahajan, SS  (2008-01-14)
Reviewed
Kavalali, E  (2008-04-24)
Created
Gillespie, ME  (2006-06-12)