Reactome | RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane]

RIMS1:UNC13B:BZRAP1:Alpha-liprin

Stable Identifier

R-HSA-210374

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Summation

Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
12871946	Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus Sun, L, Bittner, MA, Holz, RW	J Biol Chem	2003
11278839	Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells. Sun, L, Bittner, MA, Holz, RW	J Biol Chem	2001

Participants

components

Participant Of

input

output

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Inferred To

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Bos taurus)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Caenorhabditis elegans)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Canis familiaris)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Danio rerio)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Drosophila melanogaster)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Gallus gallus)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Mus musculus)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Rattus norvegicus)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Sus scrofa)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Taeniopygia guttata)

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] (Xenopus tropicalis)