Reactome | RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane]

RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane]

Stable Identifier

R-HSA-210374

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

Rab3A, located in the synaptic vesicle membrane, interacts with RIM ( Rab3A interacting Molecule) and with Doc2. These interactions are beleived to initiate the process of priming which precedes the fuison of the synaptic vesicle with the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
11278839	Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells. Holz, RW, Bittner, MA, Sun, L	J Biol Chem	2001
12871946	Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus Holz, RW, Bittner, MA, Sun, L	J Biol Chem	2003