Reactome | Release of docked serotonin loaded synaptic vesicle

Release of docked serotonin loaded synaptic vesicle

Stable Identifier

R-HSA-380901

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, clathrin-sculpted monoamine transport vesicle membrane, cytosol

ReviewStatus

5/5

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Release of docked serotonin loaded synaptic vesicle

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The trimeric complex formed between V-SNARE (VAMP) and the T-SNAREs (syntaxin and SNAP 25) after priming step is called transSNARE complex because the members of each group lie on the opposide side of the membrane, plasmamembrane side and the vesicular membrane side. Ca2+ influx through the Voltage gated Calcium Channels (VGCC) initaites the process of fusion of the synaptic vesicle in the presynaptic cell. The rise in Ca2+ leads to the activation of Protein Kinase A through rise in cAMP. Synaptotagmin, a Ca2+ sensor proetin also plays a role in the fusion process. Following fusion the members of V and T SNARES lie on the same membrane formin the cis-SNARES. The fusion of release causes the release of the neurotransmitter into the synaptic cleft.

Literature References

PubMed ID	Title	Journal	Year
12519779	Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis Fisher, RJ, Craig, TJ, Burgoyne, RD, Morgan, A, Evans, GJ, Ciufo, LF, Barclay, JW	J Biol Chem	2003
17478680	How synaptotagmin promotes membrane fusion Martens, S, McMahon, HT, Kozlov, MM	Science	2007
17891149	Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids Jahn, R, Radhakrishnan, A, Stein, A, Fasshauer, D, Riedel, D	Nat Struct Mol Biol	2007