Loss of C-Nap-1 from centrosomes

Stable Identifier
R-HSA-380294
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Loss of C-Nap-1 from centrosomes
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The centrosomal protein C-Nap1 is thought to play an important role in centrosome cohesion during interphase (Fry et al.,1998). At the onset of mitosis, when centrosomes separate to form the bipolar spindle, C-Nap1 dissociates (Mayor et al., 2000). Dissociation of C-Nap1 from mitotic centrosomes appears to be regulated by phosphorylation (Mayor et al. 2002).
Literature References
PubMed ID Title Journal Year
11076968 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

Fry, AM, Tanaka, K, Mayor, T, Nigg, EA, Stierhof, YD

J Cell Biol 2000
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Orthologous Events
Loss of C-Nap-1 from centrosomes (Bos taurus)
Loss of C-Nap-1 from centrosomes (Canis familiaris)
Loss of C-Nap-1 from centrosomes (Gallus gallus)
Loss of C-Nap-1 from centrosomes (Mus musculus)
Loss of C-Nap-1 from centrosomes (Rattus norvegicus)
Loss of C-Nap-1 from centrosomes (Sus scrofa)
Authored
Matthews, L  (2008-11-11)
Reviewed
Merdes, A  (2008-11-17)
Created
Matthews, L  (2008-11-11)
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