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What is Reactome ?
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Team
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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Docs
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How do I search ?
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Cytomics
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L-Ile [cytosol]
Stable Identifier
R-ALL-30102
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
2-Amino-3-methylvaleric acid, L-isoleucine zwitterion, L-isoleucine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Branched-chain amino acid catabolism (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Bos taurus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Bos taurus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Amino acid transport across the plasma membrane (Bos taurus)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Bos taurus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Bos taurus)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Branched-chain amino acid catabolism (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Na+/Cl- dependent neurotransmitter transporters (Caenorhabditis elegans)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Amino acid transport across the plasma membrane (Caenorhabditis elegans)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Branched-chain amino acid catabolism (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Canis familiaris)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Canis familiaris)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Amino acid transport across the plasma membrane (Canis familiaris)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Canis familiaris)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Branched-chain amino acid catabolism (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Na+/Cl- dependent neurotransmitter transporters (Danio rerio)
SLC6A15-mediated amino acid uptake (Danio rerio)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Amino acid transport across the plasma membrane (Danio rerio)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Danio rerio)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [cytosol]
L-Ile [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Branched-chain amino acid catabolism (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Branched-chain amino acid catabolism (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Drosophila melanogaster)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Drosophila melanogaster)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Branched-chain amino acid catabolism (Gallus gallus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Gallus gallus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Gallus gallus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Gallus gallus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Amino acid transport across the plasma membrane (Gallus gallus)
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Gallus gallus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [cytosol]
L-Ile [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix (Homo sapiens)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Homo sapiens)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
L-Ile [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Homo sapiens)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Homo sapiens)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Branched-chain amino acid catabolism (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Mus musculus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Na+/Cl- dependent neurotransmitter transporters (Mus musculus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Mus musculus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Amino acid transport across the plasma membrane (Mus musculus)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Mus musculus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Mus musculus)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
Na+/Cl- dependent neurotransmitter transporters (Plasmodium falciparum)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Plasmodium falciparum)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Amino acid transport across the plasma membrane (Plasmodium falciparum)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Plasmodium falciparum)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [cytosol]
L-Ile [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Branched-chain amino acid catabolism (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Rattus norvegicus)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Na+/Cl- dependent neurotransmitter transporters (Rattus norvegicus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Rattus norvegicus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Amino acid transport across the plasma membrane (Rattus norvegicus)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Rattus norvegicus)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Branched-chain amino acid catabolism (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Branched-chain amino acid catabolism (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Branched-chain amino acid catabolism (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Sus scrofa)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Na+/Cl- dependent neurotransmitter transporters (Sus scrofa)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Sus scrofa)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Amino acid transport across the plasma membrane (Sus scrofa)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Sus scrofa)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Branched-chain amino acid catabolism (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)
Leu, Ile, Val [cytosol]
L-Ile [cytosol]
Tryptophan catabolism (Xenopus tropicalis)
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Na+/Cl- dependent neurotransmitter transporters (Xenopus tropicalis)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Xenopus tropicalis)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [cytosol]
L-Ile [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Ile [cytosol]
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC6A14 ligands [cytosol]
L-Ile [cytosol]
SLC6A15-mediated amino acid uptake (Xenopus tropicalis)
ligands of SLC6A15 [cytosol]
L-Ile [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [cytosol]
L-Ile [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [cytosol]
L-Ile [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)
ligands of SLC7A8 [cytosol]
L-Ile [cytosol]
External Reference Information
External Reference
L-isoleucine zwitterion [ChEBI:58045]
Participates
as an input of
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
as a member of
ligands of SLC6A15 [cytosol]
SLC6A14 ligands [cytosol]
ligands of SLC7A8 [cytosol]
neutral amino acids [cytosol]
ligands of SLC7A5 [cytosol]
ligands of SLC43A1 and SLC43A2 [cytosol]
Leu, Ile, Val [cytosol]
Other forms of this molecule
L-Ile [extracellular region]
L-Ile [mitochondrial matrix]
Cross References
COMPOUND
C00407
ZINC
ZINC000003581355
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![L-Ile [cytosol] icon](/icon/R-ICO-014669.svg){kind=icon}
