SLC6A3 cotransports DA, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-379393
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Reuptake of dopamine from the synaptic cleft into neurons
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The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Literature References
PubMed ID Title Journal Year
10889531 Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations

Thompson, MD, Cook, EH, Uhl, GR, Comings, D, O'Dowd, BF, Vandenbergh, DJ, Nguyen, T, George, SR, Tyndale, RF, Sellers, EM, Krasowski, MD, Zarrabian, D, Bendahhou, E

Mol Psychiatry 2000
Participants
Participates
Event Information
Catalyst Activity

monoamine transmembrane transporter activity of SLC6A3 [plasma membrane]

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