The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.
Thompson, MD, Cook, EH, Uhl, GR, Comings, D, O'Dowd, BF, Vandenbergh, DJ, Nguyen, T, George, SR, Tyndale, RF, Sellers, EM, Krasowski, MD, Zarrabian, D, Bendahhou, E
monoamine transmembrane transporter activity of SLC6A3 [plasma membrane]
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