Reactome | SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol

SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol

Stable Identifier

R-HSA-379393

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

Reuptake of dopamine from the synaptic cleft into neurons

ReviewStatus

5/5

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SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol

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The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Gu et al., 1994; Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Literature References

PubMed ID	Title	Journal	Year
8125921	Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence Gu, H, Wall, SC, Rudnick, G	J Biol Chem	1994
10889531	Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations Vandenbergh, DJ, Thompson, MD, Cook, EH, Bendahhou, E, Nguyen, T, Krasowski, MD, Zarrabian, D, Comings, D, Sellers, EM, Tyndale, RF, George, SR, O'Dowd, BF, Uhl, GR	Mol Psychiatry	2000