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Na+/Cl- dependent neurotransmitter transporters
Stable Identifier
R-HSA-442660
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
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The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA (gamma-aminobutyric acid), norepinephrine, dopamine, serotonin, glycine, taurine, L-proline, creatine and betaine. These transporters are mainly present in the CNS and PNS (Chen NH et al, 2004).
Literature References
PubMed ID
Title
Journal
Year
12719981
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
Quick, MW
,
Reith, ME
,
Chen, NH
Pflugers Arch
2004
Participants
Events
GAT1-3 mediate Na+/Cl- dependent GABA transport
(Homo sapiens)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
(Homo sapiens)
Uptake of Noradrenaline
(Homo sapiens)
SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol
(Homo sapiens)
Reuptake of serotonin from the synapse
(Homo sapiens)
SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A6-mediated uptake of taurine and beta-alanine
(Homo sapiens)
PROT mediates L-proline uptake
(Homo sapiens)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A15-mediated amino acid uptake
(Homo sapiens)
VMAT1/2 can mediate the transport of biogenic amines
(Homo sapiens)
SLC6A18 transports Gly from extracellular region to cytosol
(Homo sapiens)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol
(Homo sapiens)
Participates
as an event of
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Orthologous Events
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Caenorhabditis elegans)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Danio rerio)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Mus musculus)
Na+/Cl- dependent neurotransmitter transporters (Plasmodium falciparum)
Na+/Cl- dependent neurotransmitter transporters (Rattus norvegicus)
Na+/Cl- dependent neurotransmitter transporters (Schizosaccharomyces pombe)
Na+/Cl- dependent neurotransmitter transporters (Sus scrofa)
Na+/Cl- dependent neurotransmitter transporters (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000327
Authored
Jassal, B (2009-09-29)
Reviewed
He, L (2009-11-12)
Created
Jassal, B (2009-09-29)
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