Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SLC-mediated transport of neurotransmitters
Stable Identifier
R-HSA-442660
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of neurotransmitters (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA (gamma-aminobutyric acid), norepinephrine, dopamine, serotonin, glycine, taurine, L-proline, creatine and betaine. These transporters are mainly present in the CNS and PNS (Chen NH et al, 2004).
Literature References
PubMed ID
Title
Journal
Year
12719981
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
Chen, NH
,
Reith, ME
,
Quick, MW
Pflugers Arch
2004
Participants
Events
GAT1-3 mediate Na+/Cl- dependent GABA transport
(Homo sapiens)
Uptake of Noradrenaline
(Homo sapiens)
SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol
(Homo sapiens)
SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol
(Homo sapiens)
Reuptake of serotonin from the synapse
(Homo sapiens)
SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol
(Homo sapiens)
PROT mediates L-proline uptake
(Homo sapiens)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A15-mediated amino acid uptake
(Homo sapiens)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol
(Homo sapiens)
Vesicular inhibitory amino acid transport
(Homo sapiens)
SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+
(Homo sapiens)
SLC25A18,22 import L-Glu, H+
(Homo sapiens)
Participates
as an event of
SLC-mediated transmembrane transport (Homo sapiens)
Event Information
Go Biological Process
neurotransmitter transport (0006836)
Orthologous Events
SLC-mediated transport of neurotransmitters (Bos taurus)
SLC-mediated transport of neurotransmitters (Caenorhabditis elegans)
SLC-mediated transport of neurotransmitters (Canis familiaris)
SLC-mediated transport of neurotransmitters (Danio rerio)
SLC-mediated transport of neurotransmitters (Dictyostelium discoideum)
SLC-mediated transport of neurotransmitters (Drosophila melanogaster)
SLC-mediated transport of neurotransmitters (Gallus gallus)
SLC-mediated transport of neurotransmitters (Mus musculus)
SLC-mediated transport of neurotransmitters (Plasmodium falciparum)
SLC-mediated transport of neurotransmitters (Rattus norvegicus)
SLC-mediated transport of neurotransmitters (Saccharomyces cerevisiae)
SLC-mediated transport of neurotransmitters (Sus scrofa)
SLC-mediated transport of neurotransmitters (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000327
Authored
Jassal, B (2009-09-29)
Reviewed
He, L (2009-11-12)
D'Eustachio, P (2025-08-21)
D'Eustachio, P (2025-08-26)
Created
Jassal, B (2009-09-29)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text