Reactome | LONP1 [mitochondrial matrix]

LONP1 [mitochondrial matrix]

Stable Identifier

R-HSA-9838000

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

fullName evidence="1"Lon protease homolog, mitochondrial ecNumber evidence="1"3.4.21.53/ecNumber, LONM_HUMAN

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External Reference Information

External Reference

UniProt:P36776 LONP1

Gene Names

LONP1, PRSS15

Chain

transit peptide:1-67, chain:68-959

Reference Genes

BioGPS Gene:9361 LONP1

COSMIC (genes):LONP1 LONP1

CTD Gene:9361 LONP1

dbSNP Gene:9361 LONP1

ENSEMBL:ENSG00000196365 LONP1

HGNC:9479 LONP1

KEGG:hsa:9361 LONP1

Monarch:9361 LONP1

NCBI Gene:9361 LONP1

OMIM:605490 LONP1

UCSC:P36776 LONP1

Reference Transcript

Other Identifiers

11725963_a_at

11748721_a_at

11749480_a_at

16867511

209017_PM_s_at

209017_s_at

3847357

3847358

3847359

3847360

3847362

3847363

3847366

3847367

3847368

3847369

3847370

3847371

3847373

3847374

3847375

3847376

3847377

3847379

3847380

3847381

3847382

3847383

3847385

3847386

3847387

3847389

3847390

3847391

3847392

3847393

3847394

3847395

3847396

3847397

3847398

3847399

74548_at

8033002

89584_at

9361

A_23_P208469

A_33_P3312365

GO:0000002

GO:0001666

GO:0003677

GO:0003697

GO:0003723

GO:0003727

GO:0003824

GO:0004176

GO:0004252

GO:0005515

GO:0005524

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006508

GO:0006515

GO:0007005

GO:0008236

GO:0016020

GO:0016787

GO:0016887

GO:0030163

GO:0032042

GO:0034599

GO:0035694

GO:0042645

GO:0042731

GO:0042802

GO:0043226

GO:0043531

GO:0043560

GO:0043565

GO:0046627

GO:0050730

GO:0051131

GO:0051603

GO:0051880

GO:0065003

GO:0070182

GO:0070407

GO:0140096

GO:0140657

HMNXSV003049031

ILMN_1766125

PH_hs_0016877

TC19001081.hg

g639426_3p_a_at

Participates

as a component of

LONP1 hexamer [mitochondrial matrix] (Homo sapiens)

as an output of

ATF5 activates expression of LONP1 (Homo sapiens)

Inferred To

LONP1 [mitochondrial matrix] (Bos taurus)

LONP1 [mitochondrial matrix] (Caenorhabditis elegans)

LONP1 [mitochondrial matrix] (Canis familiaris)

LONP1 [mitochondrial matrix] (Dictyostelium discoideum)

LONP1 [mitochondrial matrix] (Drosophila melanogaster)

LONP1 [mitochondrial matrix] (Gallus gallus)

LONP1 [mitochondrial matrix] (Mus musculus)

LONP1 [mitochondrial matrix] (Rattus norvegicus)

LONP1 [mitochondrial matrix] (Saccharomyces cerevisiae)

LONP1 [mitochondrial matrix] (Schizosaccharomyces pombe)

LONP1 [mitochondrial matrix] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

3180

OpenTargets

ENSG00000196365

ENSEMBL

ENSP00000468541, ENST00000360614, ENSP00000441523, ENSP00000353826, ENST00000540670, ENST00000593119

HPA

ENSG00000196365-LONP1

PRO

P36776

Pharos - Targets

P36776

GlyGen

P36776

PDB

7OXO, 6WYS, 7KSL, 7NG5, 6X27, 7P0M, 7NGF, 8OKA, 7NGL, 6WZV, 7KRZ, 2X36, 7NFY, 7NGQ, 7P0B, 8OM7, 8OJL, 7KSM, 7NG4, 7NGC, 7P09, 7NGP, 6X1M

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.643	5
UniProt:Q8IYD2 KLD8A			0.527	3
UniProt:Q96EL2 MRPS24	1	MRPS24 [mitochondrial inner membrane] (R-HSA-5368211)	0.527	3
UniProt:Q5VW00 DC122			0.527	2
UniProt:O75600 GCAT	1	PXLP-K265-GCAT [mitochondrial inner membrane] (R-HSA-535614)	0.527	3
UniProt:Q8NCR6 SMIP6			0.527	3
UniProt:Q8NA69 SAXO5			0.527	2
UniProt:Q96S79 RSLAB			0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q8WV16 DCAF4	1	DCAF4 [nucleoplasm] (R-HSA-8955191)	0.527	3
UniProt:Q9UL63 MKLN1	1	Muskelin [cytosol] (R-HSA-9861557)	0.508	2
UniProt:Q9NWT8 AURKAIP1	1	AURKAIP1 [mitochondrial inner membrane] (R-HSA-5368203)	0.483	3