Reactome | EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol]

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer

Stable Identifier

R-HSA-3780999

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

laforin:PTG:phosphoglycogen-GYG1:GYS1-a tetramer

GO Cellular Component

glycogen granule (0042587)

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18070875	Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)	J. Biol. Chem.	2008
25544560	Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease	Mol. Cell	2015
25538239	Dimeric quaternary structure of human laforin	J. Biol. Chem.	2015
16901901	Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates	J. Biol. Chem.	2006

Participants

components

Participant Of

input

output

EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex

Inferred To

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Bos taurus)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Caenorhabditis elegans)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Canis familiaris)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Danio rerio)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Drosophila melanogaster)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Gallus gallus)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Mus musculus)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Rattus norvegicus)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Sus scrofa)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Taeniopygia guttata)

EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] (Xenopus tropicalis)

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