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PANX1 [plasma membrane]
Stable Identifier
R-HSA-375344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Pannexin-1, PANX1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)
ATP:P2X7 oligomer:Pannexin-1 [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Electrical Synapses (Homo sapiens)
Electric Transmission Across Gap Junctions (Homo sapiens)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)
Pannexin 1/Pannexin 2 Gap Junction Complex [plasma membrane] (Homo sapiens)
Hemi-Pannexin 1 Complex [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RD7 PANX1
Gene Names
PANX1, MRS1, UNQ2529/PRO6028
Chain
chain:1-426
Reference Genes
BioGPS Gene:24145 PANX1
COSMIC (genes):PANX1 PANX1
CTD Gene:24145 PANX1
dbSNP Gene:24145 PANX1
ENSEMBL:ENSG00000110218 PANX1
HGNC:8599 PANX1
KEGG Gene (Homo sapiens):24145 PANX1
Monarch:24145 PANX1
NCBI Gene:24145 PANX1
OMIM:608420 PANX1
UCSC:Q96RD7 PANX1
Reference Transcript
RefSeq:NM_015368.3 PANX1
Other Identifiers
0003130152
11719239_at
11719240_at
16730180
204715_at
24145
3344991
3344992
3345000
3345007
3345008
3345010
3345011
3345012
3345013
35623_at
51075_at
7943218
A_14_P113270
A_23_P47155
A_23_P52634
A_33_P3370404
GE54774
GO:0000003
GO:0002020
GO:0002931
GO:0003674
GO:0003779
GO:0005102
GO:0005198
GO:0005243
GO:0005262
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005921
GO:0006810
GO:0006811
GO:0006812
GO:0006816
GO:0006950
GO:0007267
GO:0008092
GO:0008150
GO:0015031
GO:0015267
GO:0016020
GO:0016021
GO:0019899
GO:0022829
GO:0022840
GO:0022857
GO:0030054
GO:0030154
GO:0032059
GO:0032730
GO:0032731
GO:0032991
GO:0033198
GO:0043226
GO:0044325
GO:0044877
GO:0048477
GO:0048856
GO:0050715
GO:0050716
GO:0051015
GO:0055085
GO:0070588
GO:0097110
ILMN_1697817
PH_hs_0022092
TC11000916.hg
g7662507_3p_at
Participant Of
hasComponent
ATP:P2X7 oligomer:Pannexin-1 [plasma membrane]
Hemi-Pannexin 1 Complex [plasma membrane]
input
P2X7 mediates membrane pores that include pannexin-1
Inferred To
Panx1 [plasma membrane] (Mus musculus)
Panx1 [plasma membrane] (Rattus norvegicus)
PANX1 [plasma membrane] (Bos taurus)
PANX1 [plasma membrane] (Canis familiaris)
PANX1 [plasma membrane] (Gallus gallus)
PANX1 [plasma membrane] (Sus scrofa)
PANX1 [plasma membrane] (Xenopus tropicalis)
panx1b [plasma membrane] (Danio rerio)
Cross References
RefSeq
NP_056183.2
OpenTargets
ENSG00000110218
HPA
ENSG00000110218-PANX1
GeneCards
Q96RD7
Ensembl
ENSG00000110218
,
ENSP00000411461
,
ENST00000227638
,
ENSP00000227638
,
ENST00000436171
PRO
Q96RD7
Orphanet
28650
PDB
6WBM
,
6LTO
,
6M68
,
6V6D
,
6WBF
,
6WBL
,
6M67
,
6WBK
,
6LTN
,
6WBN
,
6WBI
,
6M66
,
6M02
,
6WBG
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.556
3
UniProt:O95183 VAMP5
0.556
3
UniProt:P41181 AQP2
3
p-S256-AQP2 [transport vesicle membrane]
(R-HSA-432222)
AQP2 [transport vesicle membrane]
(R-HSA-432215)
p-S256-AQP2 [plasma membrane]
(R-HSA-432231)
0.556
3
IntAct:EBI-23667908 CCSB ORF ID
0.556
3
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.556
3
UniProt:P02652 APOA2
6
APOA2(24-100) [extracellular region]
(R-HSA-174775)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [cytosol]
(R-HSA-2395772)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.556
3
UniProt:Q9NVC3 S38A7
0.556
3
UniProt:Q8NBD8 T229B
0.556
3
UniProt:Q92843 B2CL2
0.556
3
UniProt:Q9BQE5 APOL2
0.556
3
UniProt:Q14508 WFDC2
0.556
3
UniProt:Q9BXR6 CFHR5
1
CFHR5 [extracellular region]
(R-HSA-8851419)
0.556
3
UniProt:Q96IV6 FXDC2
0.556
3
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