Reactome | PANX1 [plasma membrane]

PANX1 [plasma membrane]

Stable Identifier

R-HSA-375344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Pannexin-1, PANX1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96RD7 PANX1

Gene Names

PANX1, MRS1, UNQ2529/PRO6028

Chain

chain:1-426

Reference Genes

BioGPS Gene:24145 PANX1

COSMIC (genes):PANX1 PANX1

CTD Gene:24145 PANX1

dbSNP Gene:24145 PANX1

ENSEMBL:ENSG00000110218.9 PANX1

HGNC:8599 PANX1

KEGG Gene (Homo sapiens):24145 PANX1

Monarch:24145 PANX1

NCBI Gene:24145 PANX1

OMIM:608420 PANX1

UCSC:Q96RD7 PANX1

Reference Transcript

RefSeq:NM_015368.3 PANX1

Other Identifiers

0003130152

11719239_at

11719240_at

16730180

204715_PM_at

204715_at

24145

3344991

3344992

3345000

3345007

3345008

3345010

3345011

3345012

3345013

35623_at

51075_at

7943218

A_14_P113270

A_23_P47155

A_23_P52634

A_33_P3370404

GE54774

GO:0002020

GO:0002376

GO:0002931

GO:0003779

GO:0005102

GO:0005198

GO:0005215

GO:0005243

GO:0005262

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005921

GO:0006811

GO:0006812

GO:0006816

GO:0007267

GO:0008092

GO:0015267

GO:0016020

GO:0016021

GO:0022414

GO:0022829

GO:0022840

GO:0023052

GO:0030154

GO:0032059

GO:0032730

GO:0032731

GO:0032732

GO:0032991

GO:0033198

GO:0043226

GO:0044325

GO:0044877

GO:0048477

GO:0048856

GO:0051015

GO:0055085

GO:0060907

GO:0070161

GO:0070588

GO:0097110

HMNXSV003009634

ILMN_1697817

PH_hs_0022092

TC11000916.hg

g7662507_3p_at

Participates

as a component of

as an input of

P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)

Inferred To

Panx1 [plasma membrane] (Mus musculus)

Panx1 [plasma membrane] (Rattus norvegicus)

PANX1 [plasma membrane] (Bos taurus)

PANX1 [plasma membrane] (Canis familiaris)

PANX1 [plasma membrane] (Gallus gallus)

PANX1 [plasma membrane] (Sus scrofa)

PANX [plasma membrane] (Danio rerio)

panx1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_056183.2

Guide to Pharmacology - Targets

735

OpenTargets

ENSG00000110218

HPA

ENSG00000110218-PANX1

GeneCards

Q96RD7

Ensembl

ENSG00000110218, ENST00000436171, ENSP00000411461, ENST00000227638, ENSP00000227638

PRO

Q96RD7

Pharos - Targets

Q96RD7

Orphanet

28650

PDB

7F8N, 6M68, 7WSV, 6WBL, 7F8O, 6M02, 6WBK, 6LTO, 7DWB, 6M66, 6M67, 6V6D, 6WBF, 6LTN, 6WBN, 7F8J, 6WBI, 6WBM, 6WBG

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95183 VAMP5			0.556	3
UniProt:P41181 AQP2	3	AQP2 [transport vesicle membrane] (R-HSA-432215) p-S256-AQP2 [transport vesicle membrane] (R-HSA-432222) p-S256-AQP2 [plasma membrane] (R-HSA-432231)	0.556	3
IntAct:EBI-23667908 CCSB ORF ID			0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q9BXR6 CFHR5	1	CFHR5 [extracellular region] (R-HSA-8851419)	0.556	3
UniProt:Q14508 WFDC2			0.556	3
UniProt:Q9BQE5 APOL2			0.556	3
UniProt:Q92843 B2CL2			0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.556	3
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.556	3
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3