Reactome | PANX1 [plasma membrane]

PANX1 [plasma membrane]

Stable Identifier

R-HSA-375344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Pannexin-1, PANX1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96RD7 PANX1

Gene Names

PANX1, MRS1, UNQ2529/PRO6028

Chain

chain:1-426

Reference Genes

BioGPS Gene:24145 PANX1

COSMIC (genes):PANX1 PANX1

CTD Gene:24145 PANX1

dbSNP Gene:24145 PANX1

ENSEMBL:ENSG00000110218 PANX1

HGNC:8599 PANX1

KEGG Gene (Homo sapiens):24145 PANX1

Monarch:24145 PANX1

NCBI Gene:24145 PANX1

OMIM:608420 PANX1

UCSC:Q96RD7 PANX1

Reference Transcript

RefSeq:NM_015368.3 PANX1

Other Identifiers

0003130152

11719239_at

11719240_at

16730180

204715_at

24145

3344991

3344992

3345000

3345007

3345008

3345010

3345011

3345012

3345013

35623_at

51075_at

7943218

A_14_P113270

A_23_P47155

A_23_P52634

A_33_P3370404

GE54774

GO:0000003

GO:0002020

GO:0002931

GO:0003674

GO:0003779

GO:0005102

GO:0005198

GO:0005243

GO:0005262

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005921

GO:0006810

GO:0006811

GO:0006812

GO:0006816

GO:0006950

GO:0007267

GO:0008092

GO:0008150

GO:0015031

GO:0015267

GO:0016020

GO:0016021

GO:0019899

GO:0022829

GO:0022840

GO:0022857

GO:0030054

GO:0030154

GO:0032059

GO:0032730

GO:0032731

GO:0032991

GO:0033198

GO:0043226

GO:0044325

GO:0044877

GO:0048477

GO:0048856

GO:0050715

GO:0050716

GO:0051015

GO:0055085

GO:0070588

GO:0097110

ILMN_1697817

PH_hs_0022092

TC11000916.hg

g7662507_3p_at

Participant Of

hasComponent

input

P2X7 mediates membrane pores that include pannexin-1

Inferred To

Panx1 [plasma membrane] (Mus musculus)

Panx1 [plasma membrane] (Rattus norvegicus)

PANX1 [plasma membrane] (Bos taurus)

PANX1 [plasma membrane] (Canis familiaris)

PANX1 [plasma membrane] (Gallus gallus)

PANX1 [plasma membrane] (Sus scrofa)

PANX1 [plasma membrane] (Xenopus tropicalis)

panx1b [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_056183.2

OpenTargets

ENSG00000110218

HPA

ENSG00000110218-PANX1

GeneCards

Q96RD7

Ensembl

ENSG00000110218, ENSP00000411461, ENST00000227638, ENSP00000227638, ENST00000436171

PRO

Q96RD7

Orphanet

28650

PDB

6WBM, 6LTO, 6M68, 6V6D, 6WBF, 6WBL, 6M67, 6WBK, 6LTN, 6WBN, 6WBI, 6M66, 6M02, 6WBG

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:P41181 AQP2	3	p-S256-AQP2 [transport vesicle membrane] (R-HSA-432222) AQP2 [transport vesicle membrane] (R-HSA-432215) p-S256-AQP2 [plasma membrane] (R-HSA-432231)	0.556	3
IntAct:EBI-23667908 CCSB ORF ID			0.556	3
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.556	3
UniProt:P02652 APOA2	6	APOA2(24-100) [extracellular region] (R-HSA-174775) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [cytosol] (R-HSA-2395772) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.556	3
UniProt:Q9NVC3 S38A7			0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q92843 B2CL2			0.556	3
UniProt:Q9BQE5 APOL2			0.556	3
UniProt:Q14508 WFDC2			0.556	3
UniProt:Q9BXR6 CFHR5	1	CFHR5 [extracellular region] (R-HSA-8851419)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3