Reactome | p-Y91,Y102-TYROBP [plasma membrane]

p-Y91,Y102-TYROBP [plasma membrane]

Stable Identifier

R-HSA-210010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y102,Y91-TYROBP, p-Y91,Y102-DAP12

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43914 TYROBP

Gene Names

TYROBP, DAP12, KARAP

Chain

signal peptide:1-21, chain:22-113

Reference Genes

BioGPS Gene:7305 TYROBP

COSMIC (genes):TYROBP TYROBP

CTD Gene:7305 TYROBP

dbSNP Gene:7305 TYROBP

ENSEMBL:ENSG00000011600 TYROBP

HGNC:12449 TYROBP

KEGG:hsa:7305 TYROBP

Monarch:7305 TYROBP

NCBI Gene:7305 TYROBP

OMIM:604142 TYROBP

UCSC:O43914 TYROBP

Reference Transcript

Other Identifiers

11723287_at

11757635_a_at

16871546

204122_PM_at

204122_at

38363_at

3860138

3860139

3860140

3860142

3860143

3860144

3860145

3860146

3860147

3860148

3860149

3860150

3860151

3860153

3860154

7305

8036224

A_23_P27994

A_33_P3409062

GE54154

GO:0001818

GO:0002222

GO:0002223

GO:0002228

GO:0002252

GO:0002274

GO:0002281

GO:0002282

GO:0002283

GO:0002291

GO:0002376

GO:0002684

GO:0005102

GO:0005515

GO:0005886

GO:0006952

GO:0006955

GO:0006968

GO:0007165

GO:0007166

GO:0007229

GO:0009986

GO:0010628

GO:0016020

GO:0016192

GO:0030036

GO:0030154

GO:0030316

GO:0030667

GO:0030674

GO:0030889

GO:0030900

GO:0032480

GO:0032481

GO:0032693

GO:0032731

GO:0032755

GO:0032760

GO:0032816

GO:0032911

GO:0032930

GO:0034241

GO:0035556

GO:0042802

GO:0042803

GO:0043277

GO:0046872

GO:0048678

GO:0048856

GO:0050821

GO:0060090

GO:0065008

GO:0071526

GO:0097242

GO:0098542

GO:1900272

GO:1902685

GO:1904151

GO:1904646

GO:2000010

GO:2001204

GO:2001206

HMNXSV003043808

ILMN_1778977

PH_hs_0028753

TC19001458.hg

TC19002463.hg

g4507754_3p_at

Participates

as a component of

p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

TYROBP [plasma membrane]

TYROBP [secretory granule membrane]

Inferred To

phospho-TYROBP [plasma membrane] (Canis familiaris)

phospho-Tyrobp [plasma membrane] (Mus musculus)

phospho-Tyrobp [plasma membrane] (Rattus norvegicus)

Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Bos taurus)

Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 91

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 102

Coordinate

102

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003323.1, NP_001166985.1, NP_937758.1

OpenTargets

ENSG00000011600

ENSEMBL

ENSP00000468447, ENST00000262629, ENSG00000011600, ENSP00000445332, ENST00000589517, ENST00000544690, ENSP00000262629

HPA

ENSG00000011600-TYROBP

GeneCards

TYROBP

PRO

O43914

Pharos - Targets

O43914

Orphanet

TYROBP

PDB

2L34, 4WOL, 4WO1, 2L35, 7Q5W

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.667	4
UniProt:Q14953 KIR2DS5	1	KIR2DS5 [plasma membrane] (R-HSA-199533)	0.591	3
UniProt:O95944 NCR2	1	NCR2 [plasma membrane] (R-HSA-197652)	0.589	2
UniProt:O43914 TYROBP	3	p-Y91,Y102-TYROBP [plasma membrane] (R-HSA-210010) TYROBP [plasma membrane] (R-HSA-198087) TYROBP [secretory granule membrane] (R-HSA-6804800)	0.558	2
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:Q08722 CD47	3	CD47 [plasma membrane] (R-HSA-197736) CD47 [specific granule membrane] (R-HSA-6799523) CD47 [tertiary granule membrane] (R-HSA-6801033)	0.527	2
UniProt:Q92538 GBF1	4	GBF1 [cytosol] (R-HSA-6807751) GBF1 [endoplasmic reticulum lumen] (R-HSA-9947748) GBF1 [lipid droplet] (R-HSA-9954446) GBF1 [Golgi membrane] (R-HSA-199994)	0.527	3
UniProt:Q8IWT6 LRRC8A	1	LRRC8A [plasma membrane] (R-HSA-8941524)	0.527	2
UniProt:Q96RD7 PANX1	1	PANX1 [plasma membrane] (R-HSA-375344)	0.527	2
UniProt:P26012 ITGB8	1	ITGB8 [plasma membrane] (R-HSA-216318)	0.527	2
UniProt:Q86VR2 RETR3			0.527	3
UniProt:Q96D05 F241B			0.527	2
UniProt:Q2TAA5 ALG11	6	ALG11 Y279S [endoplasmic reticulum membrane] (R-HSA-4570575) ALG11 E398K [endoplasmic reticulum membrane] (R-HSA-4570576) ALG11 Q318P [endoplasmic reticulum membrane] (R-HSA-4570582) ALG11 L86S [endoplasmic reticulum membrane] (R-HSA-4570580) ALG11 L381S [endoplasmic reticulum membrane] (R-HSA-4570581) ALG11 [endoplasmic reticulum membrane] (R-HSA-449267)	0.527	2
UniProt:Q86U38 NOP9			0.527	3
UniProt:Q9H1E5 TMX4			0.527	3
UniProt:Q9H3N1 TMX1			0.527	2
UniProt:Q4ZIN3 MBRL			0.527	2
UniProt:Q7Z2K6 ERMP1			0.527	2
UniProt:Q99442 SEC62			0.527	2
UniProt:Q5SWX8 ODR4			0.527	2
UniProt:Q460N5 PARP14	1	PARP14 [cytosol] (R-HSA-8938261)	0.527	2
UniProt:O00241 SIRPB1	2	SIRPB1 [secretory granule membrane] (R-HSA-6804801) SIRPB1 [plasma membrane] (R-HSA-197568)	0.524	4