Reactome | p-Y91,Y102-TYROBP [plasma membrane]

p-Y91,Y102-TYROBP [plasma membrane]

Stable Identifier

R-HSA-210010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y102,Y91-TYROBP, p-Y91,Y102-DAP12

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43914 TYROBP

Gene Names

TYROBP, DAP12, KARAP

Chain

signal peptide:1-21, chain:22-113

Reference Genes

BioGPS Gene:7305 TYROBP

COSMIC (genes):TYROBP TYROBP

CTD Gene:7305 TYROBP

dbSNP Gene:7305 TYROBP

ENSEMBL:ENSG00000011600 TYROBP

HGNC:12449 TYROBP

KEGG Gene (Homo sapiens):7305 TYROBP

Monarch:7305 TYROBP

NCBI Gene:7305 TYROBP

OMIM:604142 TYROBP

UCSC:O43914 TYROBP

Reference Transcript

Other Identifiers

0002940438

11723287_at

11757635_a_at

16871546

204122_at

38363_at

3860138

3860139

3860140

3860146

3860148

3860149

3860151

3860153

3860154

7305

8036224

A_23_P27994

A_33_P3409062

GE54154

GO:0002222

GO:0002223

GO:0002274

GO:0002282

GO:0002283

GO:0002376

GO:0003674

GO:0005102

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0006810

GO:0006950

GO:0006968

GO:0007010

GO:0007165

GO:0007267

GO:0008150

GO:0008219

GO:0008283

GO:0009986

GO:0010628

GO:0016020

GO:0016021

GO:0016192

GO:0030036

GO:0030154

GO:0030316

GO:0030667

GO:0030889

GO:0030900

GO:0031410

GO:0032693

GO:0032731

GO:0032755

GO:0032760

GO:0032816

GO:0032911

GO:0032930

GO:0034241

GO:0035556

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0043277

GO:0043312

GO:0045087

GO:0046872

GO:0048646

GO:0048678

GO:0048856

GO:0050776

GO:0050821

GO:0097190

GO:0110090

GO:1900272

GO:1901216

GO:1902685

GO:1904151

GO:2000010

GO:2001206

HMNXSV003043808

ILMN_1778977

TC19001458.hg

TC19002463.hg

g4507754_3p_at

Participates

as a component of

p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

TYROBP [secretory granule membrane]

TYROBP [plasma membrane]

Inferred To

phospho-TYROBP [plasma membrane] (Sus scrofa)

phospho-Tyrobp [plasma membrane] (Mus musculus)

phospho-Tyrobp [plasma membrane] (Rattus norvegicus)

phospho-p-Y91,Y102-TYROBP [plasma membrane] (Xenopus tropicalis)

phospho-tyrobp [plasma membrane] (Danio rerio)

Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Bos taurus)

Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Canis familiaris)

Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Gallus gallus)

Homologues of p-Y91,Y102-TYROBP [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 91

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 102

Coordinate

102

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_937758.1, NP_003323.1, NP_001166985.1

OpenTargets

ENSG00000011600

GeneCards

O43914

HPA

ENSG00000011600-TYROBP

Ensembl

ENST00000589517, ENSG00000011600, ENST00000262629, ENSP00000468447, ENST00000544690, ENSP00000262629, ENSP00000445332

PRO

O43914

Pharos - Targets

O43914

Orphanet

15678

PDB

4WOL, 4WO1, 2L34, 2L35

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.667	4
UniProt:Q14953 KIR2DS5	1	KIR2DS5 [plasma membrane] (R-HSA-199533)	0.591	3
UniProt:O95944 NCR2	1	NCR2 [plasma membrane] (R-HSA-197652)	0.589	2
UniProt:O43914 TYROBP	3	TYROBP [plasma membrane] (R-HSA-198087) p-Y91,Y102-TYROBP [plasma membrane] (R-HSA-210010) TYROBP [secretory granule membrane] (R-HSA-6804800)	0.558	2
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:O00241 SIRPB1	2	SIRPB1 [plasma membrane] (R-HSA-197568) SIRPB1 [secretory granule membrane] (R-HSA-6804801)	0.524	4

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