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p-Y91,Y102-TYROBP [plasma membrane]
Stable Identifier
R-HSA-210010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Y102,Y91-TYROBP, p-Y91,Y102-DAP12
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
p-Y91,Y102-TYROBP [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43914 TYROBP
Gene Names
TYROBP, DAP12, KARAP
Chain
signal peptide:1-21, chain:22-113
Reference Genes
BioGPS Gene:7305 TYROBP
COSMIC (genes):TYROBP TYROBP
CTD Gene:7305 TYROBP
dbSNP Gene:7305 TYROBP
ENSEMBL:ENSG00000011600 TYROBP
HGNC:12449 TYROBP
KEGG Gene (Homo sapiens):7305 TYROBP
Monarch:7305 TYROBP
NCBI Gene:7305 TYROBP
OMIM:604142 TYROBP
UCSC:O43914 TYROBP
Reference Transcript
RefSeq:NM_001173514.1 TYROBP
RefSeq:NM_003332.3 TYROBP
RefSeq:NM_198125.2 TYROBP
Other Identifiers
0002940438
11723287_at
11757635_a_at
16871546
204122_at
38363_at
3860138
3860139
3860140
3860146
3860148
3860149
3860151
3860153
3860154
7305
8036224
A_23_P27994
A_33_P3409062
GE54154
GO:0002274
GO:0002281
GO:0002282
GO:0002283
GO:0002376
GO:0003674
GO:0005102
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0006810
GO:0006950
GO:0006968
GO:0007010
GO:0007165
GO:0007229
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009986
GO:0010628
GO:0016020
GO:0016021
GO:0016192
GO:0030036
GO:0030154
GO:0030316
GO:0030667
GO:0030889
GO:0030900
GO:0031410
GO:0032693
GO:0032731
GO:0032755
GO:0032816
GO:0032911
GO:0032930
GO:0034241
GO:0035556
GO:0042535
GO:0042802
GO:0043167
GO:0043226
GO:0043277
GO:0043312
GO:0045087
GO:0046872
GO:0048646
GO:0048678
GO:0048856
GO:0050776
GO:0050821
GO:0097190
GO:0110090
GO:1900272
GO:1901216
GO:1902685
GO:1904151
GO:2000010
GO:2001204
GO:2001206
ILMN_1778977
TC19001458.hg
TC19002463.hg
g4507754_3p_at
Participant Of
hasComponent
p-Y91,Y102-DAP12 dimer [plasma membrane]
Other forms of this molecule
TYROBP [secretory granule membrane]
TYROBP [plasma membrane]
Inferred To
phospho-TYROBP [plasma membrane] (Sus scrofa)
phospho-Tyrobp [plasma membrane] (Mus musculus)
phospho-Tyrobp [plasma membrane] (Rattus norvegicus)
phospho-NFKBID [plasma membrane] (Canis familiaris)
phospho-tyrobp [plasma membrane] (Danio rerio)
Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Bos taurus)
Ghost homologue of p-Y91,Y102-TYROBP [plasma membrane] (Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 91
Coordinate
91
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 102
Coordinate
102
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003323.1
,
NP_001166985.1
,
NP_937758.1
OpenTargets
ENSG00000011600
HPA
ENSG00000011600-TYROBP
GeneCards
O43914
Ensembl
ENST00000544690
,
ENST00000262629
,
ENSP00000262629
,
ENSP00000468447
,
ENSG00000011600
,
ENST00000589517
,
ENSP00000445332
PRO
O43914
Orphanet
15678
PDB
2L35
,
4WO1
,
2L34
,
4WOL
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.667
4
UniProt:Q14953 KIR2DS5
1
KIR2DS5 [plasma membrane]
(R-HSA-199533)
0.591
3
UniProt:O95944 NCR2
1
NCR2 [plasma membrane]
(R-HSA-197652)
0.589
2
UniProt:O43914 TYROBP
3
TYROBP [plasma membrane]
(R-HSA-198087)
TYROBP [secretory granule membrane]
(R-HSA-6804800)
p-Y91,Y102-TYROBP [plasma membrane]
(R-HSA-210010)
0.558
2
UniProt:Q969S0 SLC35B4
1
SLC35B4 [Golgi membrane]
(R-HSA-742365)
0.556
3
UniProt:Q8N2M4 TM86A
0.556
3
UniProt:O00241 SIRPB1
2
SIRPB1 [plasma membrane]
(R-HSA-197568)
SIRPB1 [secretory granule membrane]
(R-HSA-6804801)
0.524
4
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