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TYROBP [secretory granule membrane]
Stable Identifier
R-HSA-6804800
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule membrane
Synonyms
DAP12, TYRO protein tyrosine kinase-binding protein precursor, TYBP_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
TYROBP [secretory granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43914 TYROBP
Gene Names
TYROBP, DAP12, KARAP
Chain
signal peptide:1-21, chain:22-113
Reference Genes
BioGPS Gene:7305 TYROBP
COSMIC (genes):TYROBP TYROBP
CTD Gene:7305 TYROBP
dbSNP Gene:7305 TYROBP
ENSEMBL:ENSG00000011600 TYROBP
ENSEMBL_homo_sapiens_GENE:ENSG00000011600.12 TYROBP
HGNC:12449 TYROBP
KEGG Gene (Homo sapiens):7305 TYROBP
Monarch:7305 TYROBP
NCBI Gene:7305 TYROBP
OMIM:604142 TYROBP
UCSC:O43914 TYROBP
Reference Transcript
RefSeq:NM_003332.3 TYROBP
RefSeq:NM_198125.2 TYROBP
RefSeq:NM_001173514.1 TYROBP
Other Identifiers
11723287_at
11757635_a_at
16871546
204122_PM_at
204122_at
38363_at
3860138
3860139
3860140
3860146
3860148
3860149
3860151
3860153
3860154
7305
8036224
A_23_P27994
A_33_P3409062
GE54154
GO:0002222
GO:0002223
GO:0002274
GO:0002282
GO:0002283
GO:0002376
GO:0005102
GO:0005515
GO:0005886
GO:0006954
GO:0006968
GO:0007010
GO:0007165
GO:0009986
GO:0010628
GO:0016020
GO:0016192
GO:0023052
GO:0030036
GO:0030154
GO:0030316
GO:0030667
GO:0030889
GO:0030900
GO:0031410
GO:0032480
GO:0032693
GO:0032731
GO:0032755
GO:0032760
GO:0032816
GO:0032911
GO:0032930
GO:0034241
GO:0035556
GO:0042802
GO:0042803
GO:0043226
GO:0043277
GO:0046872
GO:0048678
GO:0048856
GO:0050821
GO:0060090
GO:0098542
GO:1900272
GO:1902685
GO:1904151
GO:2000010
GO:2001206
HMNXSV003043808
ILMN_1778977
TC19001458.hg
TC19002463.hg
g4507754_3p_at
Participates
as a member of
Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)
Other forms of this molecule
p-Y91,Y102-TYROBP [plasma membrane]
TYROBP [plasma membrane]
Inferred To
TYROBP [secretory granule membrane]
(Canis familiaris)
TYROBP [secretory granule membrane]
(Mus musculus)
TYROBP [secretory granule membrane]
(Rattus norvegicus)
TYROBP [secretory granule membrane]
(Sus scrofa)
Cross References
RefSeq
NP_937758.1
,
NP_003323.1
,
NP_001166985.1
OpenTargets
ENSG00000011600
GeneCards
O43914
HPA
ENSG00000011600-TYROBP
Ensembl
ENSP00000262629
,
ENST00000544690
,
ENSG00000011600
,
ENSP00000468447
,
ENST00000262629
,
ENSP00000445332
,
ENST00000589517
PRO
O43914
Pharos - Targets
O43914
Orphanet
15678
PDB
2L35
,
2L34
,
4WO1
,
7Q5W
,
4WOL
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.667
4
UniProt:Q14953 KIR2DS5
1
KIR2DS5 [plasma membrane]
(R-HSA-199533)
0.591
3
UniProt:O95944 NCR2
1
NCR2 [plasma membrane]
(R-HSA-197652)
0.589
2
UniProt:O43914 TYROBP
3
p-Y91,Y102-TYROBP [plasma membrane]
(R-HSA-210010)
TYROBP [plasma membrane]
(R-HSA-198087)
TYROBP [secretory granule membrane]
(R-HSA-6804800)
0.558
2
UniProt:Q969S0 SLC35B4
1
SLC35B4 [Golgi membrane]
(R-HSA-742365)
0.556
3
UniProt:Q8N2M4 TM86A
0.556
3
UniProt:O00241 SIRPB1
2
SIRPB1 [secretory granule membrane]
(R-HSA-6804801)
SIRPB1 [plasma membrane]
(R-HSA-197568)
0.524
4
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