Interaction of NCAM1 with Major prion protein (PrP)

Stable Identifier
R-HSA-375154
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prion protein (PrP) is a GPI-anchored protein predominately localized in lipid rafts. NCAM1 is one of the membrane localized proteins that binds PrP. PrP is though to bind NCAM1 at the IgV, F3I and/or F3II domains in an interaction not involving the various carbohydrate moieties of NCAM1. The functional relevance of this interaction is unknown, but may be related to the effects of PrP on activation and proliferation of haemopoietic cells expressing NCAM1.

Participants
Participant Of
Inferred From
Authored
Reviewed
Created