Interaction of NCAM1 with Major prion protein (PrP)

Stable Identifier
R-HSA-375154
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Interaction of NCAM1 with Major prion protein (PrP)
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Prion protein (PrP) is a GPI-anchored protein predominately localized in lipid rafts. NCAM1 is one of the membrane localized proteins that binds PrP. PrP is though to bind NCAM1 at the IgV, F3I and/or F3II domains in an interaction not involving the various carbohydrate moieties of NCAM1. The functional relevance of this interaction is unknown, but may be related to the effects of PrP on activation and proliferation of haemopoietic cells expressing NCAM1.
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Output
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as an event of
Inferred From
NCAM1 binds Major prion protein (PrP) (Mus musculus)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2008-08-11)
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