NCAM1 binds Major prion protein (PrP)

Stable Identifier
R-MMU-420384
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NCAM1 binds Major prion protein (PrP)
Prion protein (PrP) is a GPI-anchored protein predominately localized in lipid rafts. NCAM1 is one of the membrane localized proteins that binds PrP. PrP is though to bind NCAM1 at the IgV, F3I and/or F3II domains in an interaction not involving the various carbohydrate moieties of NCAM1. The functional relevance of this interaction is unknown, but may be related to the effects of PrP on activation and proliferation of haemopoietic cells expressing NCAM1.
Literature References
PubMed ID Title Journal Year
11743735 Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

Bradon, N, Crossin, KL, Edelman, GM, Legname, G, Schmitt-Ulms, G, Baldwin, MA, DeArmond, SJ, Prusiner, SB, Ball, HL, Bosque, PJ, Cohen, FE

J Mol Biol 2001
Participants
Input
Output
Orthologous Events
Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-05-11)
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