Reactome | Nociceptin receptor binds to nociceptin

Nociceptin receptor binds to nociceptin

Stable Identifier

R-HSA-374723

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS.

Literature References

PubMed ID	Title	Journal	Year
9521323	Nocistatin, a peptide that blocks nociceptin action in pain transmission Okuda-Ashitaka, E, Minami, T, Tachibana, S, Yoshihara, Y, Nishiuchi, Y, Kimura, T, Ito, S	Nature	1998