Reactome | Nociceptin receptor binds to nociceptin

Nociceptin receptor binds to nociceptin

Stable Identifier

R-HSA-374723

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS.

Literature References

PubMed ID	Title	Journal	Year
9521323	Nocistatin, a peptide that blocks nociceptin action in pain transmission Yoshihara, Y, Kimura, T, Minami, T, Nishiuchi, Y, Okuda-Ashitaka, E, Ito, S, Tachibana, S	Nature	1998