Nociceptin receptor binds to nociceptin

Stable Identifier
R-HSA-374723
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The orphan nociceptin (ORL1) receptor (Mollereau C et al, 1994) is most closely related to opioid receptors on structural (sequence) and functional grounds but is not a typical opioid receptor. It may play a role in instinctive behaviours and emotions. Its natural ligand is nociceptin (orphanin FQ) (Mollereau C et al, 1996), a 17 amino acid neuropeptide which acts as a potent anti-analgesic. Both receptor and ligand are widely expressed in the CNS.

Literature References
PubMed ID Title Journal Year
9521323 Nocistatin, a peptide that blocks nociceptin action in pain transmission

Okuda-Ashitaka, E, Minami, T, Tachibana, S, Yoshihara, Y, Nishiuchi, Y, Kimura, T, Ito, S

Nature 1998
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