Reactome | CXCL10 [extracellular region]

CXCL10 [extracellular region]

Stable Identifier

R-CFA-373853

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

CXCL10(22-98), Q5KSV9

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Chemokine receptors bind chemokines (Canis familiaris)
        
        Receptor CXCR3 binds ligands CXCL9 to 11 (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Canis familiaris)
        
        CXCR3 ligands [extracellular region] (Canis familiaris)
        
        CXCL10 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q5KSV9

Gene Names

CXCL10

Reference Genes

BioGPS Gene:478432 CXCL10

ENSEMBL:ENSCAFG00040023780

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000008584.5 CXCL10

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030014095.1 CXCL10

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040023780.1 CXCL10

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805020053 CXCL10

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029862.1 CXCL10

KEGG Gene (Canis lupus familiaris):478432 CXCL10

Monarch:478432 CXCL10

NCBI Gene:478432 CXCL10

Reference Transcript

RefSeq:NM_001010949.1 CXCL10

Other Identifiers

478432

Cfa.16590.1.S1_s_at

Cfa.16590.1.S2_at

GO:0002376

GO:0005576

GO:0005615

GO:0005886

GO:0006935

GO:0006952

GO:0006955

GO:0007186

GO:0007189

GO:0008009

GO:0008201

GO:0009617

GO:0009897

GO:0010818

GO:0010819

GO:0012501

GO:0016525

GO:0023052

GO:0030154

GO:0042056

GO:0042118

GO:0042127

GO:0042981

GO:0045662

GO:0048018

GO:0048248

GO:0048856

GO:0048870

GO:0051281

GO:0051607

GO:0055065

GO:0055085

GO:0070098

GO:0071222

GO:0090026

GO:0097398

GO:0098542

GO:0098586

GO:0098772

GO:0140374

GO:1901509

GO:1901740

GO:2000406

Participates

as a member of

CXCR3 ligands [extracellular region] (Canis familiaris)

Inferred From

CXCL10(22-98) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001010949.1

OpenTargets

ENSG00000169245

Ensembl

ENSCAFT00845052887, ENSCAFP00845041528, ENSCAFG00845029862

VGNC

49645