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p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]
Stable Identifier
R-HSA-373636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Nephrin
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Nephrin binds CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin binds NCK (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin interacts with Podocin (Homo sapiens)
Podocin:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin mediated activation of N-WASP (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Phosphorylation of nephrin by FYN (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60500 NPHS1
Gene Names
NPHS1, NPHN
Chain
signal peptide:1-22, chain:23-1241
Reference Genes
BioGPS Gene:4868 NPHS1
COSMIC (genes):NPHS1 NPHS1
CTD Gene:4868 NPHS1
dbSNP Gene:4868 NPHS1
ENSEMBL:ENSG00000161270 NPHS1
HGNC:7908 NPHS1
KEGG:hsa:4868 NPHS1
Monarch:4868 NPHS1
NCBI Gene:4868 NPHS1
OMIM:602716 NPHS1
UCSC:O60500 NPHS1
Reference Transcript
RefSeq:NM_004646.3 NPHS1
Participates
as a component of
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
NPHS1 [plasma membrane]
Inferred To
Ghost homologue of p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]
(Gallus gallus)
phospho-Nphs1 [plasma membrane]
(Mus musculus)
phospho-Nphs1 [plasma membrane]
(Rattus norvegicus)
phospho-sns [plasma membrane]
(Drosophila melanogaster)
phospho-NPHS1 [plasma membrane]
(Bos taurus)
phospho-NPHS1 [plasma membrane]
(Canis familiaris)
phospho-NPHS1 [plasma membrane]
(Sus scrofa)
phospho-syg-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-nphs1 [plasma membrane]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1176
Coordinate
1176
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1193
Coordinate
1193
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1217
Coordinate
1217
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1158
Coordinate
1158
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENST00000353632
,
ENSP00000368190
,
ENSG00000161270
,
ENST00000378910
,
ENSP00000343634
OpenTargets
ENSG00000161270
GeneCards
NPHS1
HPA
ENSG00000161270-NPHS1
PRO
O60500
Pharos - Targets
O60500
GlyGen
O60500
Orphanet
NPHS1
PDB
4ZRT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.524
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.518
5
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.463
2
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