Reactome | phospho-NPHS1 [plasma membrane]

phospho-NPHS1 [plasma membrane]

Stable Identifier

R-SSC-373636

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

p-Y1158,Y1176,Y1193,Y1217-NPHS1, A0A286ZZA9

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Nephrin family interactions (Sus scrofa)
  - Nephrin binds NCK (Sus scrofa)
    - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
    - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
  - Nephrin interacts with Podocin (Sus scrofa)
    - Podocin:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
    - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
  - Nephrin mediated activation of N-WASP (Sus scrofa)
    - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
    - NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Sus scrofa)
      - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)
  - Phosphorylation of nephrin by FYN (Sus scrofa)
    - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Sus scrofa)
      - p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Sus scrofa)
        
        p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)
        
        phospho-NPHS1 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZZA9

Gene Names

NPHS1

Reference Genes

ENSEMBL:ENSSSCG00000029284.4

Other Identifiers

100622946

GO:0000165

GO:0005515

GO:0005886

GO:0005925

GO:0007010

GO:0007155

GO:0007254

GO:0007519

GO:0007520

GO:0008092

GO:0017022

GO:0023052

GO:0030154

GO:0030198

GO:0030838

GO:0032836

GO:0034330

GO:0035418

GO:0036060

GO:0042995

GO:0048856

GO:0065003

GO:0072015

Participates

as a component of

p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Sus scrofa)

Other forms of this molecule

NPHS1 [plasma membrane]

Inferred From

p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1176 (in Homo sapiens)

Coordinate

1176

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1193 (in Homo sapiens)

Coordinate

1193

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1217 (in Homo sapiens)

Coordinate

1217

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1158 (in Homo sapiens)

Coordinate

1158

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000161270

Ensembl

ENSSSCP00000036984, ENSSSCT00000044147, ENSSSCG00000029284

VGNC

90849

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