Reactome | NPHS1 [plasma membrane]

NPHS1 [plasma membrane]

Stable Identifier

R-HSA-8981500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Nephrin, NPHN_HUMAN

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External Reference Information

External Reference

UniProt:O60500 NPHS1

Gene Names

NPHS1, NPHN

Chain

signal peptide:1-22, chain:23-1241

Reference Genes

BioGPS Gene:4868 NPHS1

COSMIC (genes):NPHS1 NPHS1

CTD Gene:4868 NPHS1

dbSNP Gene:4868 NPHS1

ENSEMBL:ENSG00000161270 NPHS1

HGNC:7908 NPHS1

KEGG:hsa:4868 NPHS1

Monarch:4868 NPHS1

NCBI Gene:4868 NPHS1

OMIM:602716 NPHS1

UCSC:O60500 NPHS1

Reference Transcript

RefSeq:NM_004646.4 NPHS1

Participates

as a component of

as an input of

Nephrin trans-homophilic interaction (Homo sapiens)

Other forms of this molecule

p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]

Inferred To

Ghost homologue of NPHS1 [plasma membrane] (Gallus gallus)

sns [plasma membrane] (Drosophila melanogaster)

Nphs1 [plasma membrane] (Mus musculus)

Nphs1 [plasma membrane] (Rattus norvegicus)

NPHS1 [plasma membrane] (Bos taurus)

NPHS1 [plasma membrane] (Canis familiaris)

NPHS1 [plasma membrane] (Sus scrofa)

syg-2 [plasma membrane] (Caenorhabditis elegans)

nphs1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_004637.1

ENSEMBL

ENSP00000343634, ENSP00000368190, ENST00000353632, ENST00000378910, ENSG00000161270

OpenTargets

ENSG00000161270

GeneCards

NPHS1

HPA

ENSG00000161270-NPHS1

PRO

O60500

Pharos - Targets

O60500

GlyGen

O60500

Orphanet

NPHS1

PDB

4ZRT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.524	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.518	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.463	2

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