Reactome | NPHS1 [plasma membrane]

NPHS1 [plasma membrane]

Stable Identifier

R-HSA-8981500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Nephrin, NPHN_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60500 NPHS1

Gene Names

NPHS1, NPHN

Chain

signal peptide:1-22, chain:23-1241

Reference Genes

BioGPS Gene:4868 NPHS1

COSMIC (genes):NPHS1 NPHS1

CTD Gene:4868 NPHS1

dbSNP Gene:4868 NPHS1

ENSEMBL:ENSG00000161270 NPHS1

ENSEMBL_homo_sapiens_GENE:ENSG00000161270.20 NPHS1

HGNC:7908 NPHS1

KEGG Gene (Homo sapiens):4868 NPHS1

Monarch:4868 NPHS1

NCBI Gene:4868 NPHS1

OMIM:602716 NPHS1

UCSC:O60500 NPHS1

Reference Transcript

RefSeq:NM_004646.3 NPHS1

Other Identifiers

11737576_at

16871495

207673_3p_at

207673_PM_at

207673_at

241181_PM_x_at

241181_x_at

31967_at

3860046

3860047

3860048

3860050

3860051

3860052

3860054

3860055

3860057

3860059

3860060

3860061

3860062

3860063

3860064

3860066

3860067

3860068

3860069

3860070

3860072

3860073

3860075

3860076

3860077

3860078

3860080

3860081

3860082

3860083

3860084

3860085

3860086

3860087

4868

76445_f_at

8036176

85877_at

A_23_P5200

A_32_P121640

A_32_P13555

GE79939

GO:0000165

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005911

GO:0005925

GO:0007010

GO:0007155

GO:0007254

GO:0007517

GO:0007519

GO:0007520

GO:0008092

GO:0010467

GO:0016020

GO:0017022

GO:0023052

GO:0030154

GO:0030198

GO:0030838

GO:0032836

GO:0034330

GO:0035418

GO:0036057

GO:0036060

GO:0042995

GO:0043226

GO:0048856

GO:0050839

GO:0065003

GO:0070062

GO:0071944

GO:0072015

GO:0098609

HMNXSV003011386

Hs.270506.0.A1_3p_at

Hs.270506.0.A1_3p_x_at

ILMN_1681116

PH_hs_0030834

TC19001456.hg

g4758821_3p_at

g4758821_3p_x_at

Participates

as a component of

as an input of

Nephrin trans-homophilic interaction (Homo sapiens)

Other forms of this molecule

p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]

Inferred To

Ghost homologue of NPHS1 [plasma membrane] (Gallus gallus)

sns [plasma membrane] (Drosophila melanogaster)

Nphs1 [plasma membrane] (Mus musculus)

Nphs1 [plasma membrane] (Rattus norvegicus)

NPHS1 [plasma membrane] (Bos taurus)

NPHS1 [plasma membrane] (Canis familiaris)

NPHS1 [plasma membrane] (Sus scrofa)

syg-2 [plasma membrane] (Caenorhabditis elegans)

nphs1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_004637.1

OpenTargets

ENSG00000161270

GeneCards

O60500

HPA

ENSG00000161270-NPHS1

Ensembl

ENSG00000161270, ENST00000353632, ENSP00000343634, ENST00000378910, ENSP00000368190

PRO

O60500

Pharos - Targets

O60500

Orphanet

16566

PDB

4ZRT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.524	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.518	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.463	2

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