Receptor CXCR6 binds CXCL16 ligand

Stable Identifier
R-HSA-373358
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CXCR6 (formerly called STRL33, BONZO, and TYMSTR) was assigned this name based on its chromosomal location (within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene sequence (Liao F et al, 1997). CXCR6 is structurally more closely related to CC chemokine receptors than to other CXC chemokine receptors. It is expressed in lymphoid tissues and activated T cells and is induced in activated peripheral blood lymphocytes. CXCR6 binds the ligand CXCL16 (Shimaoka T et al, 2000) which acts as a scavenger receptor on macrophages. It specifically binds to oxidized low density lipoprotein, suggesting that it may be involved in pathophysiology such as atherogenesis.

Literature References
PubMed ID Title Journal Year
9166430 STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1

Liao, F, Alkhatib, G, Peden, KW, Sharma, G, Berger, EA, Farber, JM

J Exp Med 1997
11060282 Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages

Shimaoka, T, Kume, N, Minami, M, Hayashida, K, Kataoka, H, Kita, T, Yonehara, S

J Biol Chem 2000
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