Reactome | ELMO2 [cytosol]

ELMO2 [cytosol]

Stable Identifier

R-GGA-372642

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

ELMO2, E1C122

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
    - Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Non-Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by PTK6 (Gallus gallus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Gallus gallus)
      - Activation of RAC1 by the PXN:CRK complex (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
      - Phosphorylated PXN recruits the CRK complex (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - DOCK180:ELMO binds CRK (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
  - Signaling by Rho GTPases (Gallus gallus)
    - RHO GTPase cycle (Gallus gallus)
      - RHOG GTPase cycle (Gallus gallus)
        
        RHOG binds effectors at the plasma membrane (Gallus gallus)
        
        RHOG plasma membrane effectors [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Gallus gallus)
        
        RHOG plasma membrane effectors [cytosol] (Gallus gallus)
        
        ELMO2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1C122

Gene Names

ELMO2

Reference Genes

BioGPS Gene:419307 ELMO2

ENSEMBL:ENSGALG00000007246

ENSEMBL:ENSGALG00010016182.1 ELMO2

Monarch:419307 ELMO2

NCBI Gene:419307 ELMO2

Reference Transcript

RefSeq:XM_015296558.1 ELMO2

Other Identifiers

419307

GO:0005737

GO:0006909

GO:0006915

GO:0007010

GO:0007015

GO:0012501

GO:0016192

GO:0017124

GO:0048870

GT_A_87_P070807

Gga.10492.1.S1_at

Gga.10492.2.S1_a_at

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Gallus gallus)

as a member of

ELMO1,ELMO2 [cytosol] (Gallus gallus)

Inferred From

ELMO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015152044.1

OpenTargets

ENSG00000062598

Ensembl

ENSGALG00010016182, ENSGALP00010022471, ENSGALT00010038881