Reactome | PLEK [cytosol]

PLEK [cytosol]

Stable Identifier

R-HSA-350715

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Pleckstrin

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Release of platelet cytosolic components (Homo sapiens)
        
        Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
        
        PLEK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08567 PLEK

Gene Names

PLEK, P47

Chain

chain:1-350

Reference Genes

BioGPS Gene:5341 PLEK

COSMIC (genes):PLEK PLEK

CTD Gene:5341 PLEK

dbSNP Gene:5341 PLEK

ENSEMBL:ENSG00000115956 PLEK

HGNC:9070 PLEK

KEGG Gene (Homo sapiens):5341 PLEK

Monarch:5341 PLEK

NCBI Gene:5341 PLEK

OMIM:173570 PLEK

UCSC:P08567 PLEK

Reference Transcript

RefSeq:NM_002664.2 PLEK

Other Identifiers

0000940731

11742859_a_at

11754474_a_at

16880942

203470_s_at

203471_s_at

2486817

2486819

2486820

2486823

2486829

2486833

2486836

2486837

2486838

2486839

2486840

37328_at

5341

7896724

8042391

A_14_P129362

GE59697

GO:0002244

GO:0002376

GO:0002576

GO:0003674

GO:0005080

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006629

GO:0006810

GO:0006904

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0007229

GO:0008150

GO:0008289

GO:0009058

GO:0010572

GO:0010920

GO:0010925

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0022607

GO:0030030

GO:0030154

GO:0030836

GO:0030845

GO:0030866

GO:0031529

GO:0031532

GO:0032233

GO:0032587

GO:0033625

GO:0035556

GO:0042803

GO:0043167

GO:0043325

GO:0044281

GO:0045744

GO:0046488

GO:0048856

GO:0050849

GO:0060305

GO:0065003

GO:0070493

GO:0070527

GO:0070528

GO:0070560

HMNXSV003046590

Hs.77436.0.A1_3p_a_at

ILMN_1795762

PH_hs_0004463

TC02000398.hg

X07743_at

g4505878_3p_a_at

Participates

as a member of

Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)

Other forms of this molecule

PLEK [extracellular region]

Inferred To

Homologues of PLEK [cytosol] (Dictyostelium discoideum)

plek [cytosol] (Danio rerio)

Plek [cytosol] (Mus musculus)

Plek [cytosol] (Rattus norvegicus)

PLEK [cytosol] (Bos taurus)

PLEK [cytosol] (Canis familiaris)

PLEK [cytosol] (Dictyostelium discoideum)

PLEK [cytosol] (Gallus gallus)

PLEK [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002655.2

OpenTargets

ENSG00000115956

GeneCards

P08567

HPA

ENSG00000115956-PLEK

Ensembl

ENSG00000115956, ENST00000234313, ENSP00000234313

PRO

P08567

Pharos - Targets

P08567

PDB

2I5F, 1PLS, 2CSO, 1XX0, 1W4M, 1X05, 2I5C, 1ZM0

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.462	2
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278)	0.462	3
UniProt:P26038 MSN	4	MSN(2-448)-p-7Y ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005) MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966)	0.462	3
UniProt:P51659 HSD17B4	4	HSD17B4(1-736) [peroxisomal matrix] (R-HSA-192322) HSD17B4 [cytosol] (R-HSA-9033102) HSD17B4(312-736) [peroxisomal matrix] (R-HSA-9033495) HSD17B4(1-311) [peroxisomal matrix] (R-HSA-9033503)	0.462	2