Reactome | THBS1 [endoplasmic reticulum lumen]

THBS1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5173263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Thrombospondin 1, TSP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07996 THBS1

Gene Names

THBS1, TSP-1, Thrombospondin-1, TSP, TSP1

Chain

signal peptide:1-18, chain:19-1170

Reference Genes

COSMIC (genes):THBS1 THBS1

dbSNP Gene:7057 THBS1

ENSEMBL:ENSG00000137801 THBS1

Participates

as a member of

POFUT2 substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

glc-fuc-THBS1 [endoplasmic reticulum lumen]

O-fuc-THBS1 [endoplasmic reticulum lumen]

THBS1 [platelet alpha granule lumen]

THBS1 [extracellular region]

Inferred To

Thbs1 [endoplasmic reticulum lumen] (Mus musculus)

Thbs1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Tsp [endoplasmic reticulum lumen] (Drosophila melanogaster)

Dmel\CG9297 [endoplasmic reticulum lumen] (Drosophila melanogaster)

THBS1 [endoplasmic reticulum lumen] (Bos taurus)

THBS1 [endoplasmic reticulum lumen] (Canis familiaris)

THBS1 [endoplasmic reticulum lumen] (Gallus gallus)

THBS1 [endoplasmic reticulum lumen] (Sus scrofa)

thbs1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Homologues of THBS1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
ChEBI:28304 HEPARIN			0.702	4
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.609	2
ChEBI:18376 DERMATAN			0.609	2
heparan sulfate [ChEBI:28815]	1	HS [extracellular region] (R-ALL-190915)	0.609	2
UniProt:Q15113 PCOLCE	1	PCOLCE [extracellular region] (R-HSA-2002444)	0.558	3
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:P35442 THBS2	4	THBS2 [endoplasmic reticulum lumen] (R-HSA-5173187) glc-fuc-THBS2 [endoplasmic reticulum lumen] (R-HSA-5173234) O-fuc-THBS2 [endoplasmic reticulum lumen] (R-HSA-5173111) THBS2 [extracellular region] (R-HSA-66520)	0.527	2
UniProt:P55899 FCGRN			0.527	2
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.525	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	3

Cite Us!