Reactome | THBS1 [endoplasmic reticulum lumen]

THBS1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5173263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Thrombospondin 1, TSP1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07996 THBS1

Gene Names

THBS1, TSP, TSP1

Chain

signal peptide:1-18, chain:19-1170

Reference Genes

BioGPS Gene:7057 THBS1

COSMIC (genes):THBS1 THBS1

CTD Gene:7057 THBS1

dbSNP Gene:7057 THBS1

ENSEMBL:ENSG00000137801.11 THBS1

HGNC:11785 THBS1

KEGG Gene (Homo sapiens):7057 THBS1

Monarch:7057 THBS1

NCBI Gene:7057 THBS1

OMIM:188060 THBS1

UCSC:P07996 THBS1

Reference Transcript

RefSeq:NM_003246.3 THBS1

Other Identifiers

0004480278

115_at

11721090_at

11721091_a_at

11721092_a_at

11721093_a_at

11758842_at

16799315

201107_PM_s_at

201107_s_at

201108_PM_s_at

201108_s_at

201109_PM_s_at

201109_s_at

201110_PM_s_at

201110_s_at

235086_PM_at

235086_at

3589467

3589468

3589469

3589470

3589472

3589473

3589474

3589475

3589479

3589482

3589484

3589486

3589487

3589489

3589491

3589493

3589495

3589497

3589498

3589500

3589501

3589504

3589505

3589509

3589510

3589511

3589512

3589513

3589514

3589515

3589516

53546_at

7057

7982597

867_s_at

A_14_P135563

A_23_P206212

A_33_P3415820

GE81252

GE86195

GO:0001666

GO:0001786

GO:0001937

GO:0001953

GO:0001968

GO:0002040

GO:0002376

GO:0002544

GO:0002581

GO:0002605

GO:0003674

GO:0005178

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005577

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0006954

GO:0006955

GO:0006986

GO:0007155

GO:0008150

GO:0008201

GO:0008284

GO:0008285

GO:0008289

GO:0009410

GO:0009612

GO:0009749

GO:0009897

GO:0009986

GO:0010595

GO:0010596

GO:0010748

GO:0010751

GO:0010754

GO:0010757

GO:0010759

GO:0010763

GO:0012501

GO:0016192

GO:0016477

GO:0016525

GO:0016529

GO:0017134

GO:0018149

GO:0023052

GO:0030141

GO:0030169

GO:0030194

GO:0030312

GO:0030335

GO:0030511

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0032026

GO:0032570

GO:0032695

GO:0032760

GO:0032914

GO:0032991

GO:0033574

GO:0034330

GO:0034605

GO:0034976

GO:0036211

GO:0040037

GO:0042060

GO:0042327

GO:0042802

GO:0043032

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0043236

GO:0043394

GO:0043406

GO:0043536

GO:0043537

GO:0043652

GO:0045727

GO:0045766

GO:0048266

GO:0048661

GO:0048856

GO:0048870

GO:0050431

GO:0050840

GO:0050921

GO:0051592

GO:0051604

GO:0051895

GO:0051897

GO:0051918

GO:0055085

GO:0061024

GO:0062023

GO:0070051

GO:0070052

GO:0070062

GO:0071356

GO:0071363

GO:0071636

GO:0090051

GO:0110165

GO:1902043

GO:1903588

GO:1903671

GO:2000353

GO:2000379

GO:2001027

GO:2001237

HMNXSV003024540

Hs.42699.0.A1_3p_at

Hs.87409.0.A1_3p_a_at

Hs.87409.0.A2_3p_a_at

Hs.87409.0.A3_3p_a_at

ILMN_1686116

PH_hs_0022773

TC15000270.hg

X14787_at

g4507484_3p_a_at

Participates

as a member of

POFUT2 substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

glc-fuc-THBS1 [endoplasmic reticulum lumen]

O-fuc-THBS1 [endoplasmic reticulum lumen]

THBS1 [platelet alpha granule lumen]

THBS1 [extracellular region]

Inferred To

Thbs1 [endoplasmic reticulum lumen] (Mus musculus)

Thbs1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Tsp [endoplasmic reticulum lumen] (Drosophila melanogaster)

Dmel\CG9297 [endoplasmic reticulum lumen] (Drosophila melanogaster)

THBS1 [endoplasmic reticulum lumen] (Bos taurus)

THBS1 [endoplasmic reticulum lumen] (Canis familiaris)

THBS1 [endoplasmic reticulum lumen] (Danio rerio)

THBS1 [endoplasmic reticulum lumen] (Gallus gallus)

THBS1 [endoplasmic reticulum lumen] (Sus scrofa)

thbs1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Homologues of THBS1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_003237.2

OpenTargets

ENSG00000137801

GeneCards

P07996

HPA

ENSG00000137801-THBS1

Ensembl

ENSG00000137801, ENSP00000260356, ENST00000260356

PRO

P07996

Pharos - Targets

P07996

PDB

1Z78, 2ES3, 5FOE, 3R6B, 1ZA4, 2OUJ, 1LSL, 2ERF, 2OUH, 1UX6

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
ChEBI:18376 DERMATAN			0.609	2
ChEBI:28304 HEPARIN			0.609	3
heparan sulfate [ChEBI:28815]	1	HS [extracellular region] (R-ALL-190915)	0.609	2
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.609	2
UniProt:Q15113 PCOLCE	1	PCOLCE [extracellular region] (R-HSA-2002444)	0.558	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.525	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	3