NQO1 interaction with ODC

Stable Identifier
R-HSA-350578
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A novel pathway has been described for ODC degradation during oxidative stress, which is regulated by NAD(P)H quinone oxidoreductase (NQO1). In this pathway, the 20S proteasome has been shown to degrade unfolded ODC monomers. This event does not require the COOH-terminal domain. NQO1 binds to ODC and stabilizes it. If this interaction is disrupted with dicoumarol, it sensitizes ODC monomers to degradation by the 20S proteasome independent of both antizyme and ubiquitin. The details of the role of this pathway remains to be determined, but it could be involved in the nascent ODC chain turnover.

Literature References
PubMed ID Title Journal Year
15749015 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1

Asher, G, Bercovich, Z, Tsvetkov, P, Shaul, Y, Kahana, C

Mol Cell 2005
16205122 Mechanisms of protein degradation: an odyssey with ODC

Kahana, C, Asher, G, Shaul, Y

Cell Cycle 2005
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