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NQO1 interaction with ODC
Stable Identifier
R-HSA-350578
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
NQO1 interaction with ODC (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Asher et al. (2015) have described a process in which ODC is stabilized and protected from proteasomal degradation by interaction with NQO1 (NAD(P)H quinone oxidoreductase).
Literature References
PubMed ID
Title
Journal
Year
15749015
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
Asher, G
,
Bercovich, Z
,
Tsvetkov, P
,
Shaul, Y
,
Kahana, C
Mol Cell
2005
Participants
Input
NQO1 [cytosol]
(Homo sapiens)
PXLP-K69-ODC1 [cytosol]
(Homo sapiens)
Output
ODC:NQO1 complex [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of ornithine decarboxylase (ODC) (Homo sapiens)
Event Information
Go Biological Process
protein stabilization (0050821)
Orthologous Events
NQO1 interaction with ODC (Bos taurus)
NQO1 interaction with ODC (Canis familiaris)
NQO1 interaction with ODC (Danio rerio)
NQO1 interaction with ODC (Gallus gallus)
NQO1 interaction with ODC (Mus musculus)
NQO1 interaction with ODC (Rattus norvegicus)
NQO1 interaction with ODC (Sus scrofa)
NQO1 interaction with ODC (Xenopus tropicalis)
Authored
Gopinathrao, G (2008-05-19)
Reviewed
D'Eustachio, P (2008-06-12)
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