Reactome | NQO1 [cytosol]

NQO1 [cytosol]

Stable Identifier

R-HSA-350610

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
        
        AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)
        
        NQO1:FAD dimer [cytosol] (Homo sapiens)
        
        NQO1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15559 NQO1

Gene Names

NQO1, DIA4, NMOR1

Chain

chain:1-274

Reference Genes

BioGPS Gene:1728 NQO1

COSMIC (genes):NQO1 NQO1

CTD Gene:1728 NQO1

dbSNP Gene:1728 NQO1

ENSEMBL:ENSG00000181019.13 NQO1

HGNC:2874 NQO1

KEGG Gene (Homo sapiens):1728 NQO1

Monarch:1728 NQO1

NCBI Gene:1728 NQO1

UCSC:P15559 NQO1

Reference Transcript

Other Identifiers

11717567_a_at

11717568_s_at

16827677

16827679

1728

201467_PM_s_at

201467_s_at

201468_PM_s_at

201468_s_at

210519_PM_s_at

210519_s_at

3696674

3696675

3696676

3696677

3696678

3696679

3696681

3696683

3696686

3696687

3696689

38066_at

8002301

8002303

A_23_P206661

GE61408

GO:0002931

GO:0003723

GO:0003955

GO:0004128

GO:0004784

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0006116

GO:0006743

GO:0006766

GO:0006801

GO:0006805

GO:0006809

GO:0006979

GO:0007271

GO:0007568

GO:0007584

GO:0008753

GO:0009410

GO:0009636

GO:0009725

GO:0009743

GO:0010033

GO:0012501

GO:0014070

GO:0014075

GO:0016209

GO:0016491

GO:0019430

GO:0023052

GO:0030163

GO:0030425

GO:0032355

GO:0033574

GO:0034599

GO:0042177

GO:0042360

GO:0042373

GO:0042802

GO:0043025

GO:0043066

GO:0043086

GO:0043279

GO:0043525

GO:0045202

GO:0045454

GO:0045471

GO:0050136

GO:0051602

GO:0070301

GO:0070995

GO:0071248

GO:0098754

GO:1901698

GO:1904772

GO:1904844

GO:1904880

GO:1905395

HMNXSV003017321

Hs.80706.0.A1_3p_a_at

ILMN_1720282

ILMN_2354953

J03934_s_at

PH_hs_0019286

TC16001224.hg

TC16001225.hg

g4505414_3p_a_at

Participates

as a component of

as an input of

NQO1 interaction with ODC (Homo sapiens)

Inferred To

NQO1 [cytosol] (Bos taurus)

NQO1 [cytosol] (Canis familiaris)

NQO1 [cytosol] (Danio rerio)

NQO1 [cytosol] (Mus musculus)

NQO1 [cytosol] (Rattus norvegicus)

NQO1 [cytosol] (Sus scrofa)

nqo1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001020604.1, NP_001020605.1, NP_000894.1

ZINC - World Drugs

NQO1_HUMAN

OpenTargets

ENSG00000181019

ZINC - Substances

NQO1_HUMAN

ZINC - Biogenic

NQO1_HUMAN

ZINC target

P15559

PRO

P15559

PDB

3JSX, 5EAI, 6FY4, 5EA2, 1H69, 1QBG, 5FUQ, 5A4K, 1H66, 1KBO, 1GG5, 1DXO, 1KBQ, 4CF6, 6LLC, 1D4A, 4CET, 2F1O

HPA

ENSG00000181019-NQO1

GeneCards

P15559

Ensembl

ENST00000379047, ENSP00000319788, ENSG00000181019, ENST00000320623, ENSP00000368334, ENST00000379046, ENSP00000368335

Pharos - Targets

P15559

ZINC - Predictions - Purchasable

NQO1_HUMAN

HMDB Protein

HMDBP01689

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15559 NQO1	1	NQO1 [cytosol] (R-HSA-350610)	0.618	5
UniProt:P07902 GALT	4	GALT Q188R [cytosol] (R-HSA-5610008) GALT K285N [cytosol] (R-HSA-5610009) GALT S135L [cytosol] (R-HSA-5610004) GALT [cytosol] (R-HSA-70356)	0.556	3
UniProt:Q9UK53 ING1			0.544	3